An efficient total synthesis of (±)-galanthamine

被引：1

作者：

Guillou, C ^{[1
]}

Beunard, JL ^{[1
]}

Gras, E ^{[1
]}

Thal, C ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 24期

关键词：

alkaloids; Heck reaction; natural products; spiro compounds; total synthesis;

D O I：

10.1002/1521-3773(20011217)40:24<4745::AID-ANIE4745>3.0.CO;2-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intramolecular Heck reaction of 3 generates a spiro quaternary C atom-a key step in an efficient synthesis of galanthamine (1). Galanthamine can be readily obtained from the spiro tricyclic dienone 2, which was prepared by nonclassical dehydrogenation of the corresponding α,β-unsaturated ketone.

引用

页码：4745 / +

页数：3

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