Oral tolerance attenuates airway inflammation and remodeling in a model of chronic pulmonary allergic inflammation

被引：11
|
作者：
Schutz, Viviane C. Ruiz [1 ]
Drewiacki, Tatiana [1 ]
Nakashima, Adriane S. [1 ]
Arantes-Costa, Fernanda M. [1 ]
Prado, Carla M. [1 ]
Kasahara, David I. [1 ]
Leick-Maidonado, Edna A. [1 ]
Martins, Milton A. [1 ]
Tiberio, Iolanda F. L. C. [1 ]
机构：
[1] Univ Sao Paulo, Sch Med, Dept Med, BR-01246903 Sao Paulo, Brazil
来源：
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY | 2009年 / 165卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
Experimental model of chronic allergic inflammation; Airway collagen and elastic fibers; Oral tolerance; ASTHMA-LIKE RESPONSES; CD4(+) T-CELLS; MURINE MODEL; GUINEA-PIGS; LUNG; ANTIGEN; HYPERRESPONSIVENESS; SUPPRESSION; EXPRESSION;
D O I：
10.1016/j.resp.2008.09.007
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
We investigated the effects of oral tolerance (OT) in controlling inflammatory response, hyperresponsiveness and airway remodeling in guinea pigs (GP) with chronic allergic inflammation. Animals received seven inhalations of ovalbumin (1-5 mg/mL-OVA group) or normal saline (NS group). OT was induced by offering ad libitum ovalbumin 2% in sterile drinking water starting with the 1st ovalbumin inhalation (OT1 group) or after the 4th (OT2 group). The induction of OT in sensitized animals decreased the elastance of respiratory system (Ers) response after both antigen and methacholine challenges, peribronchial edema formation, eosinophilic airway infiltration, eosinophilopoiesis, and airways collagen and elastic fiber content compared to OVA group (P < 0.05). The number of mononuclear cells and resistance of respiratory system (Rrs) responses after antigen and methacholine challenges were decreased only in OT2 group compared to OVA group (P < 0.05). Concluding, our results show that inducing OT attenuates airway remodeling as well as eosinophilic inflammation and respiratory system mechanics. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：13 / 21
页数：9
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