Cluster of Differentiation 24 Expression Is an Independent Prognostic Factor of Adverse Outcome in Cervical Carcinoma

被引:6
|
作者
Huang, Lee-Wen [1 ,2 ,3 ]
Lee, Chin-Cheng [3 ,4 ,5 ]
机构
[1] Shin Kong Wu Ho Su Mem Hosp, Dept Obstet & Gynecol, Taipei 111, Taiwan
[2] Fu Jen Catholic Univ, Sch Med, New Taipei City, Taiwan
[3] Taipei Med Univ, Sch Med, Taipei, Taiwan
[4] Shin Kong Wu Ho Su Mem Hosp, Dept Pathol, Taipei 111, Taiwan
[5] Yuanpei Univ, Dept Nursing, Hsinchu, Taiwan
关键词
CD24; Cervical carcinoma; Prognosis; Immunohistochemistry; Tissue microarrays; CD24; EXPRESSION; CANCER; MARKER; METASTASIS; PROTEIN; SURVIVAL; LIGAND;
D O I
10.1097/IGC.0b013e318280810a
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: Cluster of differentiation (CD) 24 is a cell adhesion molecule that has been implicated in tumor invasion and metastasis of various solid tumors. The aim of this study was to explore the expression patterns of CD24 as a predictive marker for long-term survival in cervical carcinomas. Methods: A total of 144 patients diagnosed with International Federation of Gynecology and Obstetrics stage I to IV cervical carcinoma were studied, and 95 patients underwent surgical intervention. The expression of CD24 protein was studied by immunohistochemistry using tissue microarrays. Results: Overexpression of CD24 was observed in 50 (34.7%) of 144 invasive carcinomas. Patients with CD24 overexpression had poorer survival compared with that of patients with CD24 underexpression (5-year survival rate, 52.0% vs 72.3%; log rank P = 0.014). Importantly, in multivariate analysis, CD24 overexpression proved to be a significant independent predictor of short-term survival (relative risk, 1.814; P = 0.043). Conclusions: The present study suggests that CD24 overexpression is a predictor of decreased long-term survival in patients with cervical carcinoma. Therefore, immunohistochemical evaluation of CD24 expression is a potential prognostic biomarker for cervical carcinomas.
引用
收藏
页码:325 / 330
页数:6
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