Phase 0 pharmacodynamic study of poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with refractory solid tumors and lymphomas: Immunohistochemistry results

被引：3
|
作者：
Yang, S. X.
Kummar, S.
Rubinstein, L.
Gutierrez, M.
Murgo, A. J.
Parchment, R. E.
Nguyen, D.
Chen, A. P.
Tomaszewski, J. E.
Doroshow, J. H.
机构：
[1] NCI, Bethesda, MD 20892 USA
[2] SAIC Inc, Frederick, MD USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2008年 / 26卷 / 15期
关键词：
D O I：
10.1200/jco.2008.26.15_suppl.3580
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3580
引用
收藏
页数：1
相关论文
共 50 条
  • [21] Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas
    Kummar, Shivaani
    Chen, Alice
    Ji, Jiuping
    Zhang, Yiping
    Reid, Joel M.
    Ames, Matthew
    Jia, Lee
    Weil, Marcie
    Speranza, Giovanna
    Murgo, Anthony J.
    Kinders, Robert
    Wang, Lihua
    Parchment, Ralph E.
    Carter, John
    Stotler, Howard
    Rubinstein, Larry
    Hollingshead, Melinda
    Melillo, Giovanni
    Pommier, Yves
    Bonner, William
    Tomaszewski, Joseph E.
    Doroshow, James H.
    CANCER RESEARCH, 2011, 71 (17) : 5626 - 5634
  • [22] Interference with repair of sub-lethal radiation damage by ABT-888, an inhibitor of poly(ADP-ribose) polymerase (PARP), and theobromine
    Patel, Ravi
    Chiu, Song-mao
    Machtay, Mitchell
    Oleinick, Nancy
    CANCER RESEARCH, 2012, 72
  • [23] Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells
    Hsu, Heng-Wei
    de Necochea-Campion, Rosalia
    Williams, Vonetta
    Duerksen-Hughes, Penelope J.
    Simental, Alfred A., Jr.
    Ferris, Robert L.
    Chen, Chien-Shing
    Mirshahidi, Saied
    ORAL ONCOLOGY, 2014, 50 (07) : 662 - 669
  • [24] Synergistic cytotoxicity of the poly (ADP-ribose) polymerase inhibitor ABT-888 and temozolomide in dual-drug targeted magnetic nanoparticles
    Munoz-Gamez, Jose A.
    Lopez Viota, Julian
    Barrientos, Andres
    Carazo, Angel
    Sanjuan-Nunez, Laura
    Quiles-Perez, Rosa
    Munoz-de-Rueda, Paloma
    Delgado, Angel
    Ruiz-Extremera, Angeles
    Salmeron, Javier
    LIVER INTERNATIONAL, 2015, 35 (04) : 1430 - 1441
  • [25] Disposition and Drug-Drug Interaction Potential of Veliparib (ABT-888), a Novel and Potent Inhibitor of Poly(ADP-ribose) Polymerase
    Li, Xiaofeng
    Delzer, Juergen
    Voorman, Richard
    de Morais, Sonia M.
    Lao, Yanbin
    DRUG METABOLISM AND DISPOSITION, 2011, 39 (07) : 1161 - 1169
  • [26] ABT-888, an orallyactive poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
    Donawho, Cherrie K.
    Luo, Yan
    Luo, Yanping
    Penning, Thomas D.
    Bauch, Joy L.
    Bouska, Jennifer J.
    Bontcheva-Diaz, Velitchka D.
    Cox, Bryan F.
    DeWeese, Theodore L.
    Dillehay, Larry E.
    Ferguson, Debra C.
    Ghoreishi-Haack, Nayereh S.
    Grimm, David R.
    Guan, Ran
    Han, Edward K.
    Holley-Shanks, Rhonda R.
    Hristov, Boris
    Idler, Kenneth B.
    Jarvis, Ken
    Johnson, Eric F.
    Kleinberg, Lawrence R.
    Klinghofer, Vered
    Lasko, Loren M.
    Liu, Xuesong
    Marsh, Kennan C.
    McGonigal, Thomas P.
    Meulbroek, Jonathan A.
    Olson, Amanda M.
    Palma, Joann P.
    Rodriguez, Luis E.
    Shi, Yan
    Stavropoulos, Jason A.
    Tsurutani, Alan C.
    Zhu, Gui-Dong
    Rosenberg, Saul H.
    Giranda, Vincent L.
    Frost, David J.
    CLINICAL CANCER RESEARCH, 2007, 13 (09) : 2728 - 2737
  • [27] Radiosensitization of Pancreatic Cancer Cells In Vitro and In Vivo through Poly (ADP-ribose) Polymerase Inhibition with ABT-888
    Tuli, Richard
    Surmak, Andrew J.
    Reyes, Juvenal
    Armour, Michael
    Hacker-Prietz, Amy
    Wong, John
    DeWeese, Theodore L.
    Herman, Joseph M.
    TRANSLATIONAL ONCOLOGY, 2014, 7 (03): : 439 - 445
  • [28] Pharmacodynamic and pathway analysis of three presumed inhibitors of poly (ADP-ribose) polymerase: ABT-888, AZD2281, and BSI201
    Ji, Jiuping
    Lee, Maxwell P.
    Kadota, Mitsutaka
    Zhang, Yiping
    Parchment, Ralph E.
    Tomaszewski, Joseph E.
    Doroshow, James H.
    CANCER RESEARCH, 2011, 71
  • [29] A PHASE I COMBINATION STUDY OF ABT-888 AND TOPOTECAN HYDROCHLORIDE IN ADULTS WITH REFRACTORY SOLID TUMORS AND LYMPHOMAS
    Kummar, S.
    Ji, J.
    Zhang, Y.
    Simmons, D.
    Kinders, R.
    Gutierrez, M. E.
    Allen, D.
    Homeffer, Y.
    Juwara, L.
    Rubinstein, L.
    Parchment, R. E.
    Murgo, A. J.
    Chen, A.
    Tomaszewski, J. E.
    Doroshow, J. H.
    ANNALS OF ONCOLOGY, 2009, 20 : 42 - 42
  • [30] Preclinical activity of the poly (ADP-ribose) polymerase (PARP) inhibitor ABT-888 in combination with irinotecan in ovarian and triple negative breast cancers
    Nechiporchik, N.
    Lieb, K.
    Marquette, L.
    Polin, L.
    Peters, G. J.
    Chen, A.
    Ethier, S. P.
    LoRusso, P. M.
    Burger, A. M.
    EJC SUPPLEMENTS, 2010, 8 (07): : 64 - 64
12345