In order to calculate the EMU fatigue calculation of wheels, calculation of fatigue loading to obtain the wheel to solve problems, the method that makes use of multi-body dynamics simulation combined with finite element method is proposed, in time domain the wheel of CHR3 EMU in random loading is conducted the simulation study of the fatigue life. First of all, modal analysis of the wheels and wheel contact analysis are conducted in the ANSYS, and axle contact strength is also analyzed. Second, create a model of the EMU in ADAMS, and simulate to receive dynamic loading process. Finally, combined with the finite element stress method, dynamic loading time history and the linear cumulative damage rule, using ANSYS/WORKBENCH to get the fatigue life prediction chart of the wheel. It can be seen from the results, the safety factor of the most dangerous point of CRH3 EMU wheel type is 1.376, to meet fatigue life requirements, which provide a theoretical basis for the safety maintenance of the EMU.