Copper(I) Iodide-Catalysed Aerobic Oxidative Synthesis of Imidazo[1,2-a]pyridines from 2-Aminopyridines and Methyl Ketones

被引：118
|
作者：
Mohan, Darapaneni Chandra [1 ]
Donthiri, Ramachandra Reddy [1 ]
Rao, Sadu Nageswara [1 ]
Adimurthy, Subbarayappa [1 ]
机构：
[1] Cent Salt & Marine Chem Res Inst, CSIR, Acad Sci & Innovat Res, Bhavnagar 364002, Gujarat, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 11-12期
关键词：
aerobic oxidation; CH activation; copper; imidazo[1; 2-a]pyridines; zolimidine synthesis; ONE-POT SYNTHESIS; MOLECULAR-OXYGEN; FACILE SYNTHESIS; ARYL; PALLADIUM; ACID; AIR; FUNCTIONALIZATION; IMIDAZOPYRIDINES; AMINOPYRIDINES;
D O I：
10.1002/adsc.201300456
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We report here an operationally simple copper-catalysed synthesis of imidazo[1,2-a]pyridines through CH activation with oxidative linkage of two CN bonds under very mild conditions using molecular oxygen as a sole oxidant. The process allows the quick assembly of imidazo[1,2-a]pyridines including the antiulcer drug zolimidine from inexpensive and readily available 2-aminopyridines and methyl ketones with broad range of functional group tolerance.
引用
收藏
页码：2217 / 2221
页数：5
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