Non-peptide fibrinogen receptor antagonists.: 4.: The synthesis of [3H]L-756,568.

The synthesis of [H-3]L-756,568, an orally active fibrinogen receptor antagonist, is described. Two synthetic pathways were developed using either bromoindoles 2a/2b or bromoaryl sulfonamide 11 as the precursor. Use of the bromoaryl sulfonamide precursor led to [H-3]L-756,568 with higher radiochemical purity, higher radiochemical yield, and slightly higher specific activity.