The Identification of Nitric Oxide as Endothelium-Derived Relaxing Factor

被引：69
|
作者：
Loscalzo, Joseph [1 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Dept Med, Sch Med, Boston, MA 02115 USA
来源：
CIRCULATION RESEARCH | 2013年 / 113卷 / 02期
基金：
美国国家卫生研究院;
关键词：
TRINITRATE-INDUCED RELAXATION; NITROSYL-HEMOGLOBIN; S-NITROSOTHIOLS; BLOCKADE; RELEASE; NITRATE; AORTA;
D O I：
10.1161/CIRCRESAHA.113.301577
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The identification of endothelium-derived relaxing factor as nitric oxide (NO) dramatically altered the course of vascular biology, as well as other biomedical disciplines. The ubiquity of this natural product of cell metabolism and the complexity of its biochemistry provide a rich source of molecular mediators of phenotype in health and disease.
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页码：100 / 103
页数：4
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