Cardiovascular effects of nitric oxide in the rostral ventrolateral medulla of rats

被引：69
|
作者：
Kagiyama, S
Tsuchihashi, T
Abe, I
Fujishima, M
机构：
[1] Second Dept. of Internal Medicine, Fac. of Medicine, Kyushu University, Fukuoka
来源：
BRAIN RESEARCH | 1997年 / 757卷 / 01期
关键词：
nitric oxide; L-NAME; NOC; 18; medulla oblongata; rats; L-arginine; sympathetic nervous system; arterial pressure;
D O I：
10.1016/S0006-8993(97)00336-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To investigate the cardiovascular role of nitric oxide (NO) in the rostral ventrolateral medulla (RVLM), NOC 18, an NO donor, was microinjected into the RVLM of rats. NOC 18 significantly decreased mean arterial pressure (MAP). Pre-treatment with an NO trapper, carboxy-PTIO, abolished the NOC 18-induced decrease in MAP. Microinjection of L-NAME, an NO synthase inhibitor, increased MAP. L-Arginine reduced MAP and inhibited the presser response induced by L-NAME. Results suggest that NO acts on the RVLM neurons and plays an important role in cardiovascular regulation.
引用
收藏
页码：155 / 158
页数：4
相关论文
共 50 条
  • [41] CARDIOVASCULAR REGULATION BY CHOLINERGIC MECHANISMS IN ROSTRAL VENTROLATERAL MEDULLA OF SPONTANEOUSLY HYPERTENSIVE RATS
    LEE, SB
    KIM, SY
    SUNG, KW
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 205 (02) : 117 - 123
  • [42] Role of Inducible Nitric Oxide Synthase in Rostral Ventrolateral Medulla in Blood Pressure Regulation in Spontaneously Hypertensive Rats
    Kimura, Yoshikuni
    Hirooka, Yoshitaka
    Kishi, Takuya
    Ito, Koji
    Sagara, Yoji
    Sunagawa, Kenji
    CLINICAL AND EXPERIMENTAL HYPERTENSION, 2009, 31 (03) : 281 - 286
  • [43] Exercise training restores oxidative stress and nitric oxide synthases in the rostral ventrolateral medulla of renovascular hypertensive rats
    Sousa, L. E.
    Magalhaes, W. G.
    Bezerra, F. S.
    Santos, R. A. S.
    Campagnole-Santos, M. J.
    Isoldi, M. C.
    Alzamora, A. C.
    FREE RADICAL RESEARCH, 2015, 49 (11) : 1335 - 1343
  • [44] Swimming Training Modulates Nitric Oxide-Glutamate Interaction in the Rostral Ventrolateral Medulla in Normotensive Conscious Rats
    Raquel, Hiviny de A.
    Masson, Gustavo S.
    Barna, Barbara Falquetto
    Zanluqui, Nagela G.
    Pinge-Filho, Phileno
    Michelini, Lisete C.
    Martins-Pinge, Marli C.
    FRONTIERS IN PHYSIOLOGY, 2016, 7
  • [45] Cardiovascular effects produced by nitric oxide-related drugs in the caudal ventrolateral medulla
    Lage, RC
    Campagnole-Santos, MJ
    Fontes, MAP
    Santos, RAS
    NEUROREPORT, 1999, 10 (04) : 731 - 735
  • [46] Cardiovascular effects produced by interference with the local formation of nitric oxide in the ventrolateral medulla.
    Lage, RC
    CampagnoleSantos, MJ
    Santos, RAS
    HYPERTENSION, 1997, 29 (03) : 92 - 92
  • [47] CARDIOVASCULAR CONTROL BY CHOLINERGIC MECHANISMS IN THE ROSTRAL VENTROLATERAL MEDULLA
    WILLETTE, RN
    PUNNEN, S
    KRIEGER, AJ
    SAPRU, HN
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1984, 231 (02): : 457 - 463
  • [48] CARDIOVASCULAR EFFECTS OF THYROTROPIN-RELEASING-HORMONE IN NORMOTENSIVE AND HYPOTENSIVE RATS - ROLE OF ROSTRAL VENTROLATERAL MEDULLA
    YAN, J
    CHEN, HS
    LIAO, WH
    LU, SM
    CIRCULATORY SHOCK, 1992, 37 (03) : 253 - 261
  • [49] Cardiovascular and sympathetic effects of L-glutamate and glycine injected into the rostral ventrolateral medulla of conscious rats
    Sakima, A
    Yamazato, M
    Sesoko, S
    Muratani, H
    Fukiyama, K
    HYPERTENSION RESEARCH, 2000, 23 (06) : 633 - 641
  • [50] Sympathoinhibitory mechanism of moxonidine: role of the inducible nitric oxide synthase in the rostral ventrolateral medulla
    Peng, Jie
    Wang, Yang-Kai
    Wang, Li-Gang
    Yuan, Wen-Jun
    Su, Ding-Feng
    Ni, Xin
    Deng, Xiao-Ming
    Wang, Wei-Zhong
    CARDIOVASCULAR RESEARCH, 2009, 84 (02) : 283 - 291
12345