A gadolinium-complex-based theranostic prodrug for in vivo tumour-targeted magnetic resonance imaging and therapy

被引：44

作者：

Yang, Zhaoxuan ^{[1
,2
]}

Lin, Hongyu ^{[1
,2
]}

Huang, Jiaqi ^{[1
,2
]}

Li, Ao ^{[1
,2
]}

Sun, Chengjie ^{[1
,2
]}

Richmond, Jonathan ^{[3
]}

Gao, Jinhao ^{[1
,2
]}

机构：

[1] Xiamen Univ, State Key Lab Phys Chem Solid Surfaces, Key Lab Chem Biol Fujian Prov, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Dept Biol Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

[3] Newcastle Univ, Chem Nanosci Lab, Sch Nat & Environm Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 31期

基金：

中国国家自然科学基金;

关键词：

CANCER; DELIVERY; APOPTOSIS; AGENTS;

D O I：

10.1039/c9cc01816f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we report a target-specific theranostic prodrug (1a) containing Gd-DOTA, biotin, and camptothecin (CPT) along with a disulfide self-immolative linker. This prodrug exhibits selective targeting towards tumour cells and tissues, stimuli-responsive controlled release, enhanced anticancer efficacy, and accurate diagnosis and real-time monitoring via contrast-enhanced magnetic resonance imaging (MRI).

引用

页码：4546 / 4549

页数：4

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