Rethinking Glioblastoma Therapy: MDA-9/Syntenin Targeted Small Molecule

被引：13
|
作者：
Das, Swadesh K. [1 ,2 ,3 ]
Sarkar, Devanand [1 ,2 ,3 ]
Cavenee, Webster K. [4 ]
Emdad, Luni [1 ,2 ,3 ]
Fisher, Paul B. [1 ,2 ,3 ]
机构：
[1] Virginia Commonwealth Univ, Dept Human & Mol Genet, Sch Med, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Richmond, VA 23298 USA
[3] Virginia Commonwealth Univ, Sch Med, VCU Massey Canc Ctr, Richmond, VA 23298 USA
[4] Univ Calif San Diego, Ludwig Inst Canc Res, San Diego, CA 92093 USA
来源：
ACS CHEMICAL NEUROSCIENCE | 2019年 / 10卷 / 03期
关键词：
Glioblastoma multiforme; MDA-9/Syntenin; invasion; pathogenicity;
D O I：
10.1021/acschemneuro.9b00016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Effective therapies for glioblastoma multiforme (GBM) are not currently available. A small molecule has been identified using fragment-based drug-discovery guided by NMR that targets important protein-protein interactions controlling GBM invasion and pathogenicity. This first generation drug displays excellent pharmacokinetic properties, passes through the blood-brain barrier and is effective in preclinical animal models of GBM, particularly when combined with radiation therapy.
引用
收藏
页码：1121 / 1123
页数：5
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