Rethinking Glioblastoma Therapy: MDA-9/Syntenin Targeted Small Molecule

被引：13
|
作者：
Das, Swadesh K. [1 ,2 ,3 ]
Sarkar, Devanand [1 ,2 ,3 ]
Cavenee, Webster K. [4 ]
Emdad, Luni [1 ,2 ,3 ]
Fisher, Paul B. [1 ,2 ,3 ]
机构：
[1] Virginia Commonwealth Univ, Dept Human & Mol Genet, Sch Med, Richmond, VA 23298 USA
[2] Virginia Commonwealth Univ, Sch Med, VCU Inst Mol Med, Richmond, VA 23298 USA
[3] Virginia Commonwealth Univ, Sch Med, VCU Massey Canc Ctr, Richmond, VA 23298 USA
[4] Univ Calif San Diego, Ludwig Inst Canc Res, San Diego, CA 92093 USA
来源：
ACS CHEMICAL NEUROSCIENCE | 2019年 / 10卷 / 03期
关键词：
Glioblastoma multiforme; MDA-9/Syntenin; invasion; pathogenicity;
D O I：
10.1021/acschemneuro.9b00016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Effective therapies for glioblastoma multiforme (GBM) are not currently available. A small molecule has been identified using fragment-based drug-discovery guided by NMR that targets important protein-protein interactions controlling GBM invasion and pathogenicity. This first generation drug displays excellent pharmacokinetic properties, passes through the blood-brain barrier and is effective in preclinical animal models of GBM, particularly when combined with radiation therapy.
引用
收藏
页码：1121 / 1123
页数：5
相关论文
共 50 条
  • [1] Design and Synthesis of Small Molecule Probes of MDA-9/Syntenin
    Sankaranarayanan, Nehru Viji
    Villuri, Bharath Kumar
    Nagarajan, Balaji
    Lewicki, Sarah
    Das, Swadesh K.
    Fisher, Paul B.
    Desai, Umesh R.
    BIOMOLECULES, 2024, 14 (10)
  • [2] MDA-9/Syntenin Control
    Philley, Julie V.
    Kannan, Anbarasu
    Dasgupta, Santanu
    JOURNAL OF CELLULAR PHYSIOLOGY, 2016, 231 (03) : 545 - 550
  • [3] A PDZ Protein MDA-9/Syntenin: As a Target for Cancer Therapy
    Yu, Yongsheng
    Li, Shuangdi
    Wang, Kai
    Wan, Xiaoping
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2019, 17 : 136 - 141
  • [4] Targeting tumor invasion: the roles of MDA-9/Syntenin
    Kegelman, Timothy P.
    Das, Swadesh K.
    Emdad, Luni
    Hu, Bin
    Menezes, Mitchell E.
    Bhoopathi, Praveen
    Wang, Xiang-Yang
    Pellecchia, Maurizio
    Sarkar, Devanand
    Fisher, Paul B.
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2015, 19 (01) : 97 - 112
  • [5] MDA-9/syntenin is a key regulator of glioma pathogenesis
    Kegelman, Timothy P.
    Das, Swadesh K.
    Hu, Bin
    Bacolod, Manny D.
    Fuller, Christine E.
    Menezes, Mitchell E.
    Emdad, Luni
    Dasgupta, Santanu
    Baldwin, Albert S.
    Bruce, Jeffrey N.
    Dent, Paul
    Pellecchia, Maurizio
    Sarkar, Devanand
    Fisher, Paul B.
    NEURO-ONCOLOGY, 2014, 16 (01) : 50 - 61
  • [6] MDA-9/syntenin is a key regulator of glioma pathogenesis
    Kegelman, Timothy P.
    Das, Swadesh K.
    Hu, Bin
    Menezes, Mitchell
    Emdad, Luni
    Dasgupta, Santanu
    Baldwin, Albert S., Jr.
    Bruce, Jeffery N.
    Dent, Paul
    Pellecchia, Maurizio
    Sarkar, Devanand
    Fisher, Paul B.
    CANCER RESEARCH, 2013, 73
  • [7] Inhibition of radiation-induced glioblastoma invasion by genetic and pharmacological targeting of MDA-9/Syntenin
    Kegelman, Timothy P.
    Wu, Bainan
    Das, Swadesh K.
    Talukdar, Sarmistha
    Beckta, Jason M.
    Hu, Bin
    Emdad, Luni
    Valerie, Kristoffer
    Sarkar, Devanand
    Furnari, Frank B.
    Cavenee, Webster K.
    Wei, Jun
    Purves, Angela
    De, Surya K.
    Pellecchia, Maurizio
    Fisher, Paul B.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (02) : 370 - 375
  • [8] MDA-9/syntenin: a positive gatekeeper of melanoma metastasis
    Das, Swadesh K.
    Bhutia, Sujit K.
    Kegelman, Timothy P.
    Peachy, Leyla
    Oyesanya, Regina A.
    Dasgupta, Santanu
    Sokhi, Upneet K.
    Azab, Belal
    Dash, Rupesh
    Quinn, Bridget A.
    Kim, Keetae
    Barral, Paola M.
    Su, Zhao-zhong
    Boukerche, Habib
    Sarkar, Devanand
    Fisher, Paul B.
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2012, 17 : 1 - 15
  • [9] Suppression of Prostate Cancer Pathogenesis Using an MDA-9/Syntenin (SDCBP) PDZ1 Small-Molecule Inhibitor
    Das, Swadesh K.
    Kegelman, Timothy P.
    Pradhan, Anjan K.
    Shen, Xue-Ning
    Bhoopathi, Praveen
    Talukdar, Sarmistha
    Maji, Santanu
    Sarkar, Devanand
    Emdad, Luni
    Fisher, Paul B.
    MOLECULAR CANCER THERAPEUTICS, 2019, 18 (11) : 1997 - 2007
  • [10] Expression patterns of MDA-9/syntenin during development of the mouse embryo
    Jeon, Hyun Yong
    Das, Swadesh K.
    Dasgupta, Santanu
    Emdad, Luni
    Sarkar, Devanand
    Kim, Sung-Hoon
    Lee, Seok-Geun
    Fisher, Paul B.
    JOURNAL OF MOLECULAR HISTOLOGY, 2013, 44 (02) : 159 - 166
12345