Population pharmacokinetic analysis of a long-acting recombinant factor IX-FC fusion protein (RFIXFC) in patients with severe haemophilia B

被引:0
|
作者
Diao, L. [1 ]
Li, S. [2 ]
Nestorov, I. [3 ]
Jiang, H. [2 ]
机构
[1] Biogen Idec Hemophilia, Waltham, MA USA
[2] Biogen Idec Hemophilia, Preclin & Clin Res, Waltham, MA USA
[3] Biogen Idec Inc, Pharmacometr, Cambridge, MA USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:33 / 33
页数:1
相关论文
共 50 条
  • [31] Individualised Prophylaxis with Recombinant Factor IX FC Fusion Protein (RFIXFC) in Adults/Adolescents With Haemophilia B: Updated Interim Results of the B-YOND Extension Study
    Mahlangu, J. N.
    Shapiro, A. D.
    Pasi, K. J.
    Ragni, M. V.
    Ozelo, M. C.
    Oldenburg, J.
    Matsushita, T.
    Baker, R. I.
    Yuan, H.
    Ferrante, F.
    Ramirez-Santiago, A.
    Lethagen, S.
    Barnowski, C.
    HAEMOPHILIA, 2017, 23 : 85 - 86
  • [32] Recombinant factor IX-Fc fusion protein in severe hemophilia B: Patient-reported outcomes and health-related quality of life
    O'Donovan, Mairead
    Quinn, Eimear
    Johnston, Kate
    Singleton, Evelyn
    Benson, Julie
    O'Mahony, Brian
    Noone, Declan
    Duggan, Cleona
    Gilmore, Ruth
    Ryan, Kevin
    O'Donnell, James S.
    O'Connell, Niamh M.
    RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, 2021, 5 (07)
  • [33] Clinical Evaluation of a Novel, Long-Lasting Recombinant Fc Fusion Replacement Factor (Rfixfc) in Patients with Severe Hemophilia B
    Shapiro, Amy
    Pasi, John
    Gust, Stephen
    DeFeo-Fraulini, Tia
    Thomas, Gareth
    Li, Lian
    Dabora, Sandra
    Krassova, Snejana
    Luk, Alvin
    Pierce, Glenn
    AMERICAN JOURNAL OF HEMATOLOGY, 2012, 87 : S174 - S174
  • [34] Long-term safety and efficacy of recombinant factor IX Fc fusion protein (rFIXFc) in adults/adolescents with hemophilia B: Longitudinal analysis of B-LONG and B-YOND
    Mahlangu, Johnny
    Ragni, Margaret V.
    Shapiro, Amy D.
    Pasi, K. John
    Ozelo, Margareth C.
    Oldenburg, Johannes
    Matsushita, Tadashi
    Baker, Ross I.
    Feng, Ingyuan
    Ferrante, Francesca
    Ramirez-Santiago, Alejandra
    Mei, Baisong
    Barnowski, Chris
    HAEMOPHILIA, 2016, 22 : 47 - 47
  • [35] Evaluation of the toxicology, pharmacokinetics, and local tolerance of recombinant factor IX Fc (rFIXFc) fusion protein in animals
    Dumont, Jennifer A.
    Loveday, Ken
    Light, David R.
    Pierce, Glenn F.
    Jiang, Haiyan
    HAEMOPHILIA, 2014, 20 : 20 - 20
  • [36] Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein
    McCue, Justin
    Kshirsagar, Rashmi
    Selvitelli, Keith
    Lu, Qi
    Zhang, Mingxuan
    Mei, Baisong
    Peters, Robert
    Pierce, Glenn F.
    Dumont, Jennifer
    Raso, Stephen
    Reichert, Heidi
    BIOLOGICALS, 2015, 43 (04) : 213 - 219
  • [37] Extended-Interval Prophylaxis with Recombinant Factor IX FC Fusion Protein (rFIXFc) in Adults/Adolescents with Haemophilia B: Interim Results of the B-YOND Extension Study
    Mahlangu, J.
    Shapiro, A. D.
    Pasi, K. J.
    Ragni, M. V.
    Ozelo, M. C.
    Oldenburg, J.
    Matsushita, T.
    Baker, R. I.
    Yuan, H.
    Ramirez-Santiago, A.
    Pierce, G. F.
    Allen, G.
    Mei, B.
    HAEMOPHILIA, 2016, 22 : 46 - 47
  • [38] Analysis of Target Joint Bleeding with Prophylactic Use of Recombinant Factor IX Fc Fusion Protein in Patients with Severe Hemophilia B
    Shapiro, Amy D.
    Perry, David J.
    Baker, Ross I.
    Tsao, Elisa
    Mei, Baisong
    BLOOD, 2015, 126 (23)
  • [39] A prospective post-authorization safety surveillance study in Japanese hemophilia B patients with recombinant factor IX Fc fusion protein (rFIXFc)
    Hanabusa, Hideji
    Higasa, Satoshi
    Taki, Masashi
    Kobayashi, Masao
    Hashizume, Akio
    Makioka, Haruki
    Shiraishi, Mutsumi
    Hirakata, Toshiyuki
    HAEMOPHILIA, 2016, 22 : 52 - 52
  • [40] Low Bleeding Rates with Increase or Maintenance of Physical Activity in Patients Treated with Recombinant Factor IX Fc Fusion Protein ( rFIXFc) in the B-LONG and Kids B-LONG Studies
    Kulkarni, Roshni
    Shapiro, Amy D.
    Windyga, Jerzy
    Ragni, Margaret V.
    Pasi, K. John
    Ozelo, Margareth Castro
    Tsao, Elisa
    Mei, Baisong
    BLOOD, 2015, 126 (23)