Strategies for Enhancing Vaccine-Induced CTL Antitumor Immune Responses

被引:14
|
作者
Yong, Xin [1 ]
Xiao, Yu-Feng [1 ]
Luo, Gang [1 ]
He, Bin [1 ]
Lu, Mu-Han [1 ]
Hu, Chang-Jiang [1 ]
Guo, Hong [1 ]
Yang, Shi-Ming [1 ,2 ,3 ]
机构
[1] Third Mil Med Univ, Xinqiao Hosp, Dept Gastroenterol, Chongqing 400037, Peoples R China
[2] Third Mil Med Univ, Biomed Anal Ctr, Chongqing 400038, Peoples R China
[3] Third Mil Med Univ, Southwest Hosp, Chongqing Key Lab Dis Prote, Chongqing 400038, Peoples R China
关键词
T-CELL RESPONSES; DENDRITIC CELLS; CANCER-IMMUNOTHERAPY; TUMOR; ACTIVATION; MECHANISMS; INHIBITION; ANTIGEN; PERFORIN; FAS;
D O I
10.1155/2012/605045
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Vaccine-induced cytotoxic T lymphocytes (CTLs) play a critical role in adaptive immunity against cancers. An important goal of current vaccine research is to induce durable and long-lasting functional CTLs that can mediate cytotoxic effects on tumor cells. To attain this goal, there are four distinct steps that must be achieved. To initiate a vaccine-induced CTL antitumor immune response, dendritic cells (DCs) must capture antigens derived from exogenous tumor vaccines in vivo or autologous DCs directly loaded in vitro with tumor antigens must be injected. Next, tumor-antigen-loaded DCs must activate CTLs in lymphoid organs. Subsequently, activated CTLs must enter the tumor microenvironment to perform their functions, at which point a variety of negative regulatory signals suppress the immune response. Finally, CTL-mediated cytotoxic effects must overcome the tolerance induced by tumor cells. Each step is a complex process that may be impeded in many ways. However, if these steps happen under appropriate regulation, the vaccine-induced CTL antitumor immune response will be more successful. For this reason, we should gain a better understanding of the basic mechanisms that govern the immune response. This paper, based on the steps necessary to induce an immune response, discusses current strategies for enhancing vaccine-induced CTL antitumor immune responses.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Enhancing Inactivated Yellow Fever 17D Vaccine-Induced Immune Responses in Balb/C Mice Using Alum/CpG
    Zhang, Yadan
    Yang, Rong
    Yuan, Guangying
    Li, Weidong
    Cui, Zihao
    Xiao, Zhuangzhuang
    Dong, Xiaofei
    Yang, Hongqiang
    Liu, Xiaojuan
    Zhang, Le
    Hou, Yirong
    Liu, Manyu
    Liu, Sushi
    Hao, Yu
    Zhang, Yuntao
    Zheng, Xiaotong
    VACCINES, 2023, 11 (12)
  • [42] Chemotherapy enhances vaccine-induced antitumor immunity in melanoma patients
    Nistico, Paola
    Capone, Imerio
    Palermo, Belinda
    Del Bello, Duilia
    Ferraresi, Virginia
    Moschella, Federica
    Arico, Eleonora
    Valentini, Mara
    Bracci, Laura
    Cognetti, Francesco
    Ciccarese, Mariangela
    Vercillo, Giuseppe
    Roselli, Mario
    Fossile, Emanuela
    Tosti, Maria Elena
    Wang, Ena
    Marincola, Francesco
    Imberti, Luisa
    Catricala, Caterina
    Natali, Pier Giorgio
    Belardeli, Filippo
    Proietti, Enrico
    INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (01) : 130 - 139
  • [43] THE RELATIONSHIP BETWEEN INFLUENZA VACCINE-INDUCED SPECIFIC ANTIBODY-RESPONSES AND VACCINE-INDUCED NONSPECIFIC AUTOANTIBODY RESPONSES IN HEALTHY OLDER WOMEN
    HUANG, YP
    GAUTHEY, L
    MICHEL, M
    LORETO, M
    PACCAUD, M
    PECHERE, JC
    MICHEL, JP
    JOURNALS OF GERONTOLOGY, 1992, 47 (02): : M50 - M55
  • [44] Immune Responses in Malaria and Vaccine Strategies
    Ferluga, Janez
    Singh, Iesha
    Rout, Sashmita
    Al-Qahtani, Ahmed
    Yasmin, Hadida
    Kishore, Uday
    MICROBIAL PATHOGENESIS: INFECTION AND IMMUNITY, 2ND EDITION, 2021, 1313 : 273 - 291
  • [45] Mucosa and vaccine-induced immune protection in nonhuman primates
    Mattapallil, Joseph J.
    Roederer, Mario
    CURRENT OPINION IN HIV AND AIDS, 2008, 3 (03) : 387 - 392
  • [46] NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia
    Leung, Halina H. L.
    Perdomo, Jose
    Ahmadi, Zohra
    Zheng, Shiying S.
    Rashid, Fairooj N.
    Enjeti, Anoop
    Ting, Stephen B.
    Chong, James J. H.
    Chong, Beng H.
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [47] Vaccine-Induced Immune Thrombocytopenia and Thrombosis after the Sputnik V Vaccine
    Herrera-Comoglio, Raquel
    Lane, Samantha
    NEW ENGLAND JOURNAL OF MEDICINE, 2022, 387 (15): : 1431 - 1432
  • [48] Antibiotics modulate vaccine-induced humoral immune response
    Woo, PCY
    Tsoi, HW
    Wong, LP
    Leung, HCH
    Yuen, KY
    CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 1999, 6 (06) : 832 - 837
  • [49] Vaccine-induced immune thrombotic thrombocytopenia and patients with cancer
    Connors, Jean M.
    Iba, Toshiaki
    THROMBOSIS RESEARCH, 2022, 213 : S77 - S83
  • [50] Eltrombopag for refractory vaccine-induced immune thrombotic thrombocytopenia
    Giorgio Maraziti
    Cecilia Becattini
    Journal of Thrombosis and Thrombolysis, 2022, 53 : 954 - 958