Cerebrospinal fluid carnitine levels in patients with Parkinson's disease

被引：11

作者：

JimenezJimenez, FJ

Rubio, JC

Molina, JA

Martin, MA

Campos, Y

BenitoLeon, J

OrtiPareja, M

Gasalla, T

Arenas, J

机构：

[1] UNIV ALCALA DE HENARES, HOSP PRINCIPE ASTURIAS, DEPT NEUROL, ALCALA DE HENARES, SPAIN

[2] HOSP 12 OCTUBRE, DEPT BIOCHEM, E-28041 MADRID, SPAIN

[3] HOSP 12 OCTUBRE, DEPT NEUROL, E-28041 MADRID, SPAIN

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1997年 / 145卷 / 02期

关键词：

Parkinson's disease; oxidative stress; carnitine; mitochondrial function; plasma; cerebrospinal fluid;

D O I：

10.1016/S0022-510X(96)00259-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We assessed free carnitine (FC) and acyl-carnitine esters (AC) in both CSF and plasma from 29 patients with diagnostic criteria for PD, and from 29 healthy matched-controls. FC and AC levels in both CSF and plasma did not differ significantly between PD patients and controls, they were not influenced significantly by anti-parkinsonian drugs, and did not correlate with age at onset, duration and severity of PD. These results suggest that CSF carnitine levels are apparently unrelated with the risk for PD. (C) 1997 Elsevier Science B.V.

引用

页码：183 / 185

页数：3

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