Efficient Synthesis of Pamidronic Acid Using an Ionic Liquid Additive

被引：12

作者：

Grun, Alajos ^{[1
]}

Nagy, David Illes ^{[1
]}

Garadnay, Sandor ^{[2
]}

Greiner, Istvan ^{[2
]}

Keglevich, Gyorgy ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary

[2] Gedeon Richter Plc, H-1475 Budapest, Hungary

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2016年 / 13卷 / 06期

关键词：

Pamidronic acid; best synthesis; additive; ionic liquids; intermediate; BISPHOSPHONATES;

D O I：

10.2174/1570180812666151022221805

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient method was developed for the synthesis of pamidronic acid involving the reaction of beta-alanine with three equivalents of phosphorus trichloride and two equivalents of phosphorous acid at 75 degrees C in the presence of 0.3 or 0.6 equivalents of [BMIM][PF6] as an additive.

引用

页码：475 / 478

页数：4

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