Identification of the structural elements of P-REX1 required for activation by phosphatidylinositol 3,4,5-trisphosphate and G protein βγ dimers

被引：0
|
作者：
Walliser, C [1 ]
Gierschik, P [1 ]
Illenberger, D [1 ]
机构：
[1] Univ Ulm, Dept Pharmacol & Toxicol, D-89081 Ulm, Germany
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2004年 / 369卷
关键词：
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
190
引用
收藏
页码：R48 / R48
页数：1
相关论文
共 50 条
  • [21] A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B
    Lova, P
    Paganini, S
    Hirsch, E
    Barberis, L
    Wymann, M
    Sinigaglia, F
    Balduini, C
    Torti, M
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (01) : 131 - 138
  • [22] Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils
    Cash, Jennifer N.
    Chandan, Naincy R.
    Hsu, Alan Y.
    Sharma, Prateek, V
    Deng, Qing
    Smrcka, Alan, V
    Tesmer, John J. G.
    MOLECULAR PHARMACOLOGY, 2020, 97 (03) : 226 - 236
  • [23] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
    Currie, Richard A.
    Walker, Kay S.
    Gray, Alex
    Deak, Maria
    Casamayor, Antonio
    Downes, C. Peter
    Cohen, Philip
    Alessi, Dado R.
    Lucocq, John
    Biochemical Journal, 1999, 337 (pt 3): : 575 - 583
  • [24] Def-6, a phosphatidylinositol 3,4,5-trisphosphate binding protein, are involved in the formation of membrane ruffling
    Oka, T
    Ihara, S
    Fukui, Y
    MOLECULAR BIOLOGY OF THE CELL, 2004, 15 : 387A - 387A
  • [25] Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
    Currie, RA
    Walker, KS
    Gray, A
    Deak, M
    Casamayor, A
    Downes, CP
    Cohen, P
    Alessi, DR
    Lucocq, J
    BIOCHEMICAL JOURNAL, 1999, 337 : 575 - 583
  • [26] Rac activation:: P-Rex1 -: A convergence point for PIP3 and Gβγ?
    Weiner, OD
    CURRENT BIOLOGY, 2002, 12 (12) : R429 - R431
  • [27] Identification of multiple phosphoinositide-specific phospholipases D as new regulatory enzymes for phosphatidylinositol 3,4,5-trisphosphate
    Ching, TT
    Wang, DS
    Hsu, AL
    Lu, PJ
    Chen, CS
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (13) : 8611 - 8617
  • [28] Identification of multiple phosphoinositide-specific phospholipases D as new regulatory enzymes for phosphatidylinositol 3,4,5-trisphosphate
    J Biol Chem, 13 (8611-8617):
  • [29] P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac
    Welch, HCE
    Coadwell, WJ
    Ellson, CD
    Ferguson, GJ
    Andrews, SR
    Erdjument-Bromage, H
    Tempst, P
    Hawkins, PT
    Stephens, LR
    CELL, 2002, 108 (06) : 809 - 821
  • [30] IDENTIFICATION OF PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE IN PANCREATIC-ISLETS AND INSULIN-SECRETING BETA-CELLS
    ALTER, CA
    WOLF, BA
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 208 (01) : 190 - 197
12345