Epidermal growth factor and pro-inflammatory cytokines regulate the expression of components of plasminogen activation system in U373-MG astrocytoma cells

被引：20
|
作者：
Kasza, A
Kowanetz, M
Poslednik, K
Witek, B
Kordula, T
Koj, A [1 ]
机构：
[1] Jagiellonian Univ, Inst Mol Biol, Dept Cell Biochem, PL-30387 Krakow, Poland
[2] Cleveland State Univ, Dept Biol Geol & Environm Sci, Cleveland, OH 44115 USA
来源：
CYTOKINE | 2001年 / 16卷 / 05期
关键词：
IL-1; IFN-gamma; TNF-alpha; EGF; PAI-1;
D O I：
10.1006/cyto.2001.0957
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cytokines and growth factors that influence both secretion of the extracellular matrix (ECM) proteins and migration of the cells decide about the final outcome of tissue remodelling. We have examined expression of the components of the plasminogen activation system in human astrocytoma U373-MG cells and found that interleukin 1beta (IL-1beta), tumour necrosis factor a TNF-alpha interferon gamma (INF-gamma) and epidermal growth factor (EGF) specifically regulate the expression of tissue-type plasminogen activator (t-PA), urokinase-type plasminogen activator (u-PA), plasminogen activator inhibitor type I (PAI-1) and protease nexin-1 (PN-1). We conclude that EGF and IFN-gamma are new important regulators of the plasminogen activation system in astrocytoma cells and, therefore, may influence turnover of extracellular matrix and migration of cells within the brain. (C) 2001 Academic Press.
引用
收藏
页码：187 / 190
页数：4
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