High seroconversion rates in Trypanosoma cruzi chronic infection treated with benznidazole in people under 16 years in Guatemala

被引:4
|
作者
Brum-Soares, Lucia [1 ]
Cubides, Juan-Carlos [1 ]
Burgos, Iris [1 ]
Monroy, Carlota [2 ]
Castillo, Leticia [3 ]
Gonzalez, Selene [3 ]
Vinas, Pedro Albajar [4 ]
Palma Urrutia, Pedro Pablo [5 ]
机构
[1] Med Sem Fronteiras, Unidade Med Brasileira, Rio De Janeiro, RJ, Brazil
[2] San Carlos Univ, Lab Med & Parasit Entomol, Guatemala City, Guatemala
[3] Natl Lab Publ Hlth, Dept Parasitol, Guatemala City, Guatemala
[4] WHO, Dept Control Neglected Trop Dis, Geneva, Switzerland
[5] Doctors Borders, Dept Med, Barcelona, Spain
关键词
Benznidazole; Chagas; Chronic infection; Guatemala; Seroconversion; CHRONIC CHAGAS-DISEASE; TRIAL; HONDURAS; SAFETY;
D O I
10.1590/0037-8682-0415-2016
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Introduction: Geographical, epidemiological, and environmental differences associated with therapeutic response to Chagas etiological treatment have been previously discussed. This study describes high seroconversion rates 72 months after benznidazole treatment in patients under 16 years from a project implemented by Doctors without Borders in Guatemala. Methods: An enzyme-linked immunosorbent assay was used to detect Trypanosoma cruzi IgG antibodies in capillary blood samples from patients 72 months after treatment. Fisher's exact test was used to establish association between characteristics, such as sex, age, and origin of patients, and final seroconversion. Kappa index determined concordance between laboratory tests. The level of significance was set to 5%. Results: Ninety-eight patients, aged 6 months to 16 years, were available for follow-up. Sex and origin were not associated with seroconversion. Individuals older than 13 were more prone to maintain a positive result 72 months after treatment, although results were not highly significant. Laboratory tests presented elevated Kappa concordance (95% CI) = 0.8290 (0.4955-1), as well as high (97%) seroconversion rates. Conclusions: The high seroconversion rate found in this study emphasizes the importance of access to diagnosis, treatment, and follow-up of individuals affected by Chagas disease. Moreover, it contradicts the idea that it is not possible to achieve a cure with the currently available drugs. This study strongly supports expanding programs for patients infected with T. cruzi in endemic and non-endemic countries.
引用
收藏
页码:721 / 727
页数:7
相关论文
共 37 条
  • [21] PCR reveals significantly higher rates of Trypanosoma cruzi infection than microscopy in the Chagas vector, Triatoma infestans: High rates found in Chuquisaca, Bolivia
    Juan Carlos Pizarro
    David E Lucero
    Lori Stevens
    BMC Infectious Diseases, 7
  • [22] Course of serological tests in treated subjects with chronic Trypanosoma cruzi infection: A systematic review and meta-analysis of individual participant data
    Sguassero, Yanina
    Roberts, Karen N.
    Harvey, Guillermina B.
    Comande, Daniel
    Ciapponi, Agustin
    Cuesta, Cristina B.
    Aguiar, Camila
    de Castro, Ana M.
    Danesi, Emmaria
    de Andrade, Ana L.
    de Lana, Marta
    Escriba, Josep M.
    Fabbro, Diana L.
    Fernandes, Cloe D.
    Flores-Chavez, Maria
    Hasslocher-Moreno, Alejandro M.
    Jackson, Yves
    Lacunza, Carlos D.
    Machado-de-Assis, Girley F.
    Maldonado, Marisel
    Meira, Wendell S. F.
    Molina, Israel
    Monje-Rumi, Maria M.
    Munoz-San Martin, Catalina
    Murcia, Laura
    de Castro, Cleudson Nery
    Sanchez Negrette, Olga
    Segovia, Manuel
    Silveira, Celeste A. N.
    Solari, Aldo
    Steindel, Mario
    Streiger, Mirtha L.
    Vera de Bilbao, Ninfa
    Zulantay, Ines
    Sosa-Estanib, Sergio
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2018, 73 : 93 - 101
  • [23] High rates of early HBeAg seroconversion and relapse in Indian patients of chronic hepatitis B treated with Lamivudine: results of an open labeled trial
    Alexander, G
    Baba, CS
    Chetri, K
    Negi, TS
    Choudhuri, G
    BMC GASTROENTEROLOGY, 2005, 5 (1)
  • [24] High rates of early HBeAg seroconversion and relapse in Indian patients of chronic hepatitis B treated with Lamivudine: results of an open labeled trial
    George Alexander
    Chalamalasetty S Baba
    Kamal Chetri
    TS Negi
    Gourdas Choudhuri
    BMC Gastroenterology, 5
  • [25] Behavioral and biological parameters of six populations of Triatoma pallidipennis (Heteroptera: Reduviidae) from areas with high and low prevalence rates of Trypanosoma cruzi human infection
    Meraz-Medina, Tzintli
    Grant-Guillen, Yunuen
    Mercado-Trujillo, Jose Rodrigo
    Nogueda-Torres, Benjamin
    Martinez-Ibarra, Jose Alejandro
    ACTA TROPICA, 2024, 256
  • [26] CHARACTERIZATION OF A NATURAL HUMAN-ANTIBODY WITH ANTI-GALACTOSYL(ALPHA-1-2)GALACTOSE SPECIFICITY THAT IS PRESENT AT HIGH TITERS IN CHRONIC TRYPANOSOMA-CRUZI INFECTION
    AVILA, JL
    ROJAS, M
    VELAZQUEZAVILA, G
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1992, 47 (04): : 413 - 421
  • [27] High infection rates of Triatoma dimidiata are associated with low levels of Trypanosoma cruzi seroprevalence in Pedro Carbo, Ecuador.: Use of a TC24 gene-based PCR approach
    Guevara, AG
    Garzón, E
    Bowen, C
    Córdova, X
    Gómez, E
    Ouaissi, A
    PARASITE, 2005, 12 (01) : 65 - 68
  • [28] High response and re-infection rates among people who inject drugs treated for hepatitis C in a community needle and syringe programme
    Schulkind, Jasmine
    Stephens, Brian
    Ahmad, Farsana
    Johnston, Linda
    Hutchinson, Sharon
    Thain, Donna
    Ward, Zoe
    Vickerman, Peter
    Hickman, Matt
    Dillon, John F.
    JOURNAL OF VIRAL HEPATITIS, 2019, 26 (05) : 519 - 528
  • [29] Effectiveness of therapy in 16, 567 directly-acting antiviral treated people in England: high response rates in genotype 3 hepatitis C infection regardless of degree of fibrosis, but ribavirin improves response in cirrhosis
    Drysdale, Kate
    Townley, Ceri
    Mahomed, Faizel
    Foster, Graham
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E131 - E131
  • [30] TITLE: PREVALENCE OF CHRONIC VIRAL HEPATITIS IN SOUTH ASIANS IMMIGRANTS - PEOPLE FROM PAKISTAN HAVE HIGH RATES OF INFECTION WITH HEPATITIS C AND HIGH RATES OF HEPATITIS C INDUCED CIRRHOSIS IN MIDDLE AGE
    Uddin, Gias
    Faster, Graham R.
    HEPATOLOGY, 2008, 48 (04) : 533A - 533A