Response to vecuronium in a patient with facioscapulohumeral muscular dystrophy

被引：4

作者：

Nitahara, K ^{[1
]}

Sakuragi, T ^{[1
]}

Matsuyama, M ^{[1
]}

Dan, K ^{[1
]}

机构：

[1] Fukuoka Univ, Sch Med, Dept Anesthesiol, Jonan Ku, Fukuoka 8140180, Japan

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1999年 / 83卷 / 03期

关键词：

neuromuscular block; vecuronium; complications; muscular dystrophy;

D O I：

10.1093/bja/83.3.499

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Increased sensitivity to vecuronium has been noted in patients with Duchenne muscular dystrophy. We report the response to vecuronium in a patient with facioscapulohumeral muscular dystrophy (FSHD), an autosomal dominant disorder with an incidence of 10-20 cases per million. In this patient, sensitivity to an initial dose of vecuronium (0.02 + 0.08 mg kg(-1)) was normal, but recovery was faster and the effect of incremental doses of vecuronium (0.02 mg kg(-1)) was less than expected. Onset time and 25% recovery of T1/T0 after the intubating dose of vecuronium were 240 s and 22 min, respectively. Recovery index (spontaneous recovery of T1/T0 from 25% to 75%) was 9 min.

引用

页码：499 / 500

页数：2

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