Synthesis, Antimicrobial Activities and Molecular Docking Studies of Novel 6-Hydroxybenzofuran-3(2H)-one Based 2,4-Disubstituted 1,3-Thiazoles

被引：0

作者：

Laczkowski, Krzysztof Z. ^{[1
]}

Misiura, Konrad ^{[1
]}

Biernasiuk, Anna ^{[2
]}

Malm, Anna ^{[2
]}

Siwek, Agata ^{[3
]}

Plech, Tomasz ^{[3
]}

机构：

[1] Nicholas Copernicus Univ, Fac Pharm, Dept Chem Technol & Pharmaceut, Coll Med, PL-85089 Bydgoszcz, Poland

[2] Med Univ Lublin, Fac Pharm, Dept Pharmaceut Microbiol, PL-20093 Lublin, Poland

[3] Med Univ Lublin, Fac Pharm, Dept Organ Chem, PL-20093 Lublin, Poland

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2013年 / 10卷 / 09期

关键词：

Thiazoles; Thiosemicarbazones; Benzofuranone; Antimicrobial drugs; N-myristoyltransferase; Molecular modeling; FUNGAL N-MYRISTOYLTRANSFERASE; IN-VITRO ACTIVITY; ANTIFUNGAL AGENTS; CRYSTAL-STRUCTURE; CANDIDA-ALBICANS; 2-THIAZOLYLHYDRAZONE DERIVATIVES; BIOLOGICAL EVALUATION; ASYMMETRIC-SYNTHESIS; INHIBITORS; THIAZOLES;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis, characterization and investigation of antibacterial and antifungal activities of thirteen novel 6-hydroxybenzofuran-3(2H)-one based 2,4-disubstituted 1,3-thiazoles are presented. Their structures were determined using NMR, FAB MS and HRMS analyses. The results of microbiological screening reveal that three derivatives containing fluorine, bromine and hydrogen substituents at the phenyl ring are the most active antimicrobial compounds. Molecular docking studies of all compounds on the active sites of microbial enzymes indicated a possible target N-myristoyltransferase (NMT).

引用

页码：798 / 807

页数：10

共 50 条

[41] SYNTHESIS OF 2,4-DISUBSTITUTED 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINES IN 1,3-INDANEDIONE SERIES
MAGDESIEVA, NN
CHOVNIKOVA, NG
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1989, (03): : 379 - 381
[42] SYNTHESIS, ANTIMICROBIAL ACTIVITY, α-AMYLASE INHIBITORY TESTS AND MOLECULAR DOCKING STUDIES OF THIAZOLE BASED HYDRAZONES DERIVED FROM 2-ACYL-(1H)-INDENE-1,3(2H)-DIONES
Mor, S.
Khatri, M.
Sindhu, S.
Punia, R.
Nagoria, S.
Kumar, A.
Kumar, A.
PHARMACEUTICAL CHEMISTRY JOURNAL, 2022, 56 (07) : 925 - 934
[43] Synthesis, biological evaluation and molecular docking studies of novel 3,5-disubstituted 2,4-thiazolidinediones derivatives
Srivastava, Alok Ranjan
Bhatia, Rohit
Chawla, Pooja
BIOORGANIC CHEMISTRY, 2019, 89
[44] Synthesis, quantum mechanical calculations, antimicrobial activities and molecular docking studies of five novel 2,5-disubstituted benzoxazole derivatives
Temiz-Arpaci, Ozlem
Zeyrek, Celal Tugrul
Arisoy, Mustafa
Erol, Meryem
Celik, Ismail
Kaynak-Onurdag, Fatma
JOURNAL OF MOLECULAR STRUCTURE, 2021, 1245
[45] 1,3-OXAZINES AND RELATED-COMPOUNDS .12. FACILE SYNTHESIS OF 2,4-DISUBSTITUTED 6H-1,3-OXAZIN-6-ONES
YAMAMOTO, Y
MORITA, Y
MINAMI, K
CHEMICAL & PHARMACEUTICAL BULLETIN, 1986, 34 (05) : 1980 - 1986
[46] Novel pyrano [3,2-b]xanthen-7(2H)-ones: Synthesis, antimicrobial, antioxidant and molecular docking studies
Ashok, Dongamanti
Devulapally, Mohan Gandhi
Aamate, Vikas Kumar
Gundu, Srinivas
Adam, Shaik
Murthy, S. D. S.
Balasubramanian, Sridhar
Naveen, Baindla
Parthasarathy, Tigulla
JOURNAL OF MOLECULAR STRUCTURE, 2019, 1177 : 215 - 228
[47] Novel hybrid isoindole-1,3(2H)-dione compounds containing a 1H-tetrazole moiety: Synthesis, biological evaluation, and molecular docking studies
Tan, Ayse
Kizilkaya, Serap
Noma, Samir A. A.
Ates, Burhan
Kara, Yunus
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2022, 36 (05)
[48] Novel one-pot expeditious synthesis of 2,4-disubstituted thiazoles through a three-component reaction under solvent free conditions
Sujatha, Kodam
Vedula, Rajeswar Rao
SYNTHETIC COMMUNICATIONS, 2018, 48 (03) : 302 - 308
[49] Novel 2,4-disubstituted quinazolines as cytotoxic agents and JAK2 inhibitors: Synthesis, in vitro evaluation and molecular dynamics studies
Buggana, Siva Jyothi
Paturi, Mani Chandrika
Perka, Harathi
Reddy, Gade Deepak
Prasad, V. V. S. Rajendra
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2019, 79 : 110 - 118
[50] Synthesis and antimicrobial activity of some 2-(4′,5′-disubstituted thiazolo)-1H-isoindole-1,3(2H)-diones/succinimides
Rajpurohit, S
Sah, P
ASIAN JOURNAL OF CHEMISTRY, 2005, 17 (04) : 2251 - 2256

← 1 2 3 4 5 →