Data integration in the era of omics: current and future challenges

被引:227
|
作者
Gomez-Cabrero, David [1 ,2 ]
Abugessaisa, Imad [1 ,2 ]
Maier, Dieter [3 ]
Teschendorff, Andrew [4 ]
Merkenschlager, Matthias [5 ]
Gisel, Andreas [6 ]
Ballestar, Esteban [7 ]
Bongcam-Rudloff, Erik [8 ]
Conesa, Ana [9 ]
Tegner, Jesper [1 ,2 ]
机构
[1] Karolinska Inst, Dept Med, Ctr Mol Med, Unit Computat Med, Stockholm, Sweden
[2] Karolinska Univ Hosp, Stockholm, Sweden
[3] Biomax Informat AG, Munich, Germany
[4] UCL, UCL Canc Inst, Ctr Math & Phys Life Sci & Expt Biol, London WC1E 6BT, England
[5] Univ London Imperial Coll Sci Technol & Med, Lymphocyte Dev Grp, MRC Clin Sci Ctr, London W12 0NN, England
[6] Ist Tecnol Biomed CNR, Unita Org, I-70126 Bari, Italy
[7] Bellvitge Biomed Res Inst IDIBELL, Canc Epigenet & Biol Program PEBC, Chromatin & Dis Grp, Barcelona, Spain
[8] Swedish Univ Agr Sci, SLU Global Bioinformat Ctr, Dept Anim Breeding & Genet, Uppsala, Sweden
[9] Ctr Invest Principe Felipe, Computat Genom Program, Valencia, Spain
关键词
GENE-EXPRESSION; DATA SETS; METAANALYSIS; KNOWLEDGE; GENOMICS; NETWORK; DISCOVERY; NATION; GROWTH;
D O I
10.1186/1752-0509-8-S2-I1
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
To integrate heterogeneous and large omics data constitutes not only a conceptual challenge but a practical hurdle in the daily analysis of omics data. With the rise of novel omics technologies and through large-scale consortia projects, biological systems are being further investigated at an unprecedented scale generating heterogeneous and often large data sets. These data-sets encourage researchers to develop novel data integration methodologies. In this introduction we review the definition and characterize current efforts on data integration in the life sciences. We have used a web-survey to assess current research projects on data-integration to tap into the views, needs and challenges as currently perceived by parts of the research community.
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页数:10
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