Dilated cardiomyopathy (DCM) is characterized by progressive reduction in contractile function and by dilatation of the right and left ventricles. Abnormalities of the cellular and Immoral immune system are present in patients with myocarditis and DCM. Several antibodies against cardiac structures have been detected in DCM patients. The functional significance of cardiac autoantibodies is under debate. For certain antibodies, in vitro data indicate a negative effect on cardiac performance. Furthermore, recent data have provided evidence that cardiac antibodies themselves induce DCM. Cardiac antibodies belong to the IgG fraction and can be eliminated by immunoadsorption therapy. Recent clinical studies showed that removal of antibodies by immunoadsorption improves cardiac function of patients with DCM, indicating that activation of the humoral immune system plays a functional role in DCM.
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Matsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, JapanMatsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, Japan
Yazaki, Yoshikazu
Takahashi, Ayako
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Matsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, JapanMatsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, Japan
Takahashi, Ayako
Horigome, Mitsuaki
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Matsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, JapanMatsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, Japan
Horigome, Mitsuaki
Kasai, Hiroki
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机构:Matsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, Japan
Kasai, Hiroki
Izawa, Atsushi
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Shinshu Univ, Sch Med, Div Cardiovasc Med, Matsumoto, Nagano 390, JapanMatsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, Japan
Izawa, Atsushi
Ikeda, Uichi
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Shinshu Univ, Sch Med, Div Cardiovasc Med, Matsumoto, Nagano 390, JapanMatsumoto Hosp, NHO Matsumoto Med Ctr, Div Cardiol, Matsumoto, Nagano, Japan