Easy access to synthesize isoquinolines from aryl ketoximes and internal alkynes via Iridium (III)-catalyzed C-H/N-O bond activation

被引：13
|
作者：
Lin, Wei [1 ]
Hu, Xiu-Xiu [1 ]
Zhuang, Cang-Wei [1 ]
Wang, Ya-Zhen [1 ]
机构：
[1] Jiangsu Univ Technol, Sch Chem & Environm Engn, Changzhou 213001, Peoples R China
来源：
TETRAHEDRON | 2019年 / 75卷 / 22期
关键词：
Isoquinoline; Synthesis; Cyclization; Iridium(III)-catalysis; H FUNCTIONALIZATION; BETA-PHENYLETHYLAMINES; DIRECTING GROUPS; 4+2 ANNULATION; N-OXIDE; AMIDATION; OXIMES; ALKYNYLATION; HETEROCYCLES; CYCLIZATION;
D O I：
10.1016/j.tet.2019.04.039
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient approach to synthesize isoquinoline derivatives through Iridium(III)-catalyzed cyclization of aryl ketoximes and internal alkynes without oxidant is reported. A broad range isoquinolines are obtained in good to excellent yields and various functional groups are well tolerated. (C) 2019 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3015 / 3023
页数：9
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