miR-208a-3p suppresses cell apoptosis by targeting PDCD4 in gastric cancer

被引：36

作者：

Yin, Kai ^{[1
,2
,3
]}

Liu, Minghui ^{[2
]}

Zhang, Mei ^{[4
]}

Wang, Feng ^{[1
]}

Fen, Min ^{[1
]}

Liu, Zhijian ^{[5
]}

Yuan, Yutao ^{[5
]}

Gao, Shanting ^{[5
]}

Yang, Liuqing ^{[5
]}

Zhang, Weijie ^{[1
]}

Zhang, Jianguo ^{[6
]}

Guo, Baoliang ^{[6
]}

Xu, Jianwei ^{[3
]}

Liang, Hongwei ^{[2
]}

Chen, Xi ^{[2
]}

Guan, Wenxian ^{[1
]}

机构：

[1] Nanjing Med Univ, Clin Coll, Nanjing Drum Tower Hosp, Dept Gastrointestinal Surg, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Univ, Sch Life Sci, Jiangsu Engn Res Ctr MicroRNA Biol & Biotechnol, State Key Lab Pharmaceut Biotechnol,NJU Adv Inst, Nanjing 210046, Jiangsu, Peoples R China

[3] Bengbu Med Sch, Taixing Hosp, Dept Gen Surg, Taixing 225400, Jiangsu, Peoples R China

[4] Bengbu Med Sch, Taixing Hosp, Dept Anesthesiol, Taixing 225400, Jiangsu, Peoples R China

[5] Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Gastrointestinal Surg, Nanjing 210008, Jiangsu, Peoples R China

[6] Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin 150081, Heilongjiang, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 41期

基金：

中国国家自然科学基金;

关键词：

gastric cancer; microRNA; miR; 208a-3p; PDCD4; apoptosis; DEATH; 4; PDCD4; DOWN-REGULATION; EXPRESSION; ESOPHAGEAL; GROWTH; PROLIFERATION; MICRORNA-21; BIOGENESIS; MANAGEMENT; CARCINOMA;

D O I：

10.18632/oncotarget.12006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Programmed cell death 4 (PDCD4) is a novel tumor suppressor gene and a promising target for anticancer therapies. PDCD4 is frequently downregulated in various human cancers; however, the molecular mechanism accounting for the loss expression of PDCD4 in cancers is not fully understood. In this study, we identified specific targeting sites for miR-208a-3p in the 3'-untranslated region (3'-UTR) of the PDCD4 gene which regulated PDCD4 expression. We demonstrated that miR-208a-3p suppressed apoptosis in gastric cancer cells by targeting PDCD4. We also showed that miR-208a-3p promoted the development of tumor growth in xenograft mice by negatively regulating PDCD4. Taken together, this study revealed a critical role for miR-208a-3p as an oncogenic miRNA in gastric carcinogenesis and it may provide a potential novel target for gastric cancer diagnosis and therapy.

引用

页码：67321 / 67332

页数：12

共 50 条

[21] MicroRNA-150 inhibitors enhance cell apoptosis of melanoma by targeting PDCD4
Wan, Jianji
Yang, Jie
Huang, Yueshen
Deng, Liehua
ONCOLOGY LETTERS, 2018, 15 (02) : 1475 - 1482
[22] Circular RNA hsa_circ_0026344 suppresses gastric cancer cell proliferation, migration and invasion via the miR-590-5p/PDCD4 axis
Lv, Long
Du, Jinghu
Wang, Daorong
Yan, Zeqiang
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2022, 74 (08) : 1193 - 1203
[23] MicroRNA-16 Promotes Ovarian Granulosa Cell Proliferation and Suppresses Apoptosis Through Targeting PDCD4 in Polycystic Ovarian Syndrome
Fu, Xiafei
He, Yuanli
Wang, Xuefeng
Peng, Dongxian
Chen, Xiaoying
Li, Xinran
Wan, Qing
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 48 (02) : 670 - 682
[24] The role of MiR-21 and Pdcd4 in colorectal cancer
Peacock, O.
Lee, A.
Cameron, F.
Tufarelli, C.
Lund, J.
BRITISH JOURNAL OF SURGERY, 2012, 99 : 24 - 24
[25] MiR-499-5p protects cardiomyocytes against ischaemic injury via anti-apoptosis by targeting PDCD4
Li, Yingqing
Lu, Jianhua
Bao, Xueming
Wang, Xifu
Wu, Junhua
Li, Xiongbin
Hong, Weiqiang
ONCOTARGET, 2016, 7 (24) : 35607 - 35617
[26] TGF-β1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells
Pin Guo
Yanan Yu
Huanting Li
Daoxiang Zhang
Anjing Gong
Shifang Li
Wei Liu
Lei Cheng
Yongming Qiu
Weicheng Yao
Luo Li
Yugong Feng
Scientific Reports, 7
[27] Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4
J Xiao
Y Pan
X H Li
X Y Yang
Y L Feng
H H Tan
L Jiang
J Feng
X Y Yu
Cell Death & Disease, 2016, 7 : e2277 - e2277
[28] Circular RNA ITCH Suppresses Cell Proliferation but Induces Apoptosis in Oral Squamous Cell Carcinoma by Regulating miR-421/PDCD4 Axis
Hao, Chunbo
Wangzhou, Kaixin
Liang, Zhengeng
Liu, Cheng
Wang, Linlin
Gong, Lei
Tan, Yi
Li, Conghui
Lai, Zhiying
Hu, Guangwei
CANCER MANAGEMENT AND RESEARCH, 2020, 12 : 5651 - 5658
[29] Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4
Xiao, J.
Pan, Y.
Li, X. H.
Yang, X. Y.
Feng, Y. L.
Tan, H. H.
Jiang, L.
Feng, J.
Yu, X. Y.
CELL DEATH & DISEASE, 2016, 7 : e2277 - e2277
[30] MiR-21-5p enhances the progression and paclitaxel resistance in drug-resistant breast cancer cell lines by targeting PDCD4
Tao, L.
Wu, Y. Q.
Zhang, S. P.
NEOPLASMA, 2019, 66 (05) : 746 - 755

← 1 2 3 4 5 →