Polysaccharide isolated from Chinese jujube fruit (Zizyphus jujuba cv. Junzao) exerts anti-inflammatory effects through MAPK signaling

被引：72
|
作者：
Zhan, Rui [1 ]
Xia, Long [2 ]
Shao, Jinhui [3 ]
Wang, Cheng [1 ]
Chen, Daofeng [2 ]
机构：
[1] Xinjiang Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Key Lab Agroprod Qual & Safety Xinjiang, Urumq 830091, Peoples R China
[2] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 201203, Peoples R China
[3] Xinjiang Univ, Coll Life Sci & Technol, Urumqi 830046, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2018年 / 40卷
关键词：
Zizyphus jujuba cv. Junzao; Anti-inflammatory activity; Pectic polysaccharide; Cytokines; Lipopolysaccharide; NF-KAPPA-B; INDUCED INFLAMMATORY RESPONSE; RAW; 264.7; MACROPHAGES; STRUCTURAL-CHARACTERIZATION; SOLUBLE POLYSACCHARIDES; CHEMICAL-COMPOSITION; NITRIC-OXIDE; IFN-GAMMA; IN-VITRO; LIPOPOLYSACCHARIDE;
D O I：
10.1016/j.jff.2017.11.026
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
A peptic polysaccharide (ZJP) was isolated from Zizyphus jujuba cv. Junzao by hot water extraction and chromatographic purification. Structural characterization showes that LIP has a weight-average molecular weight of 153.3 kDa and consists of galacturonic acid. The linkage type of ZJP was proven to be 1,4-linked D-GalpA by methylation, NMR and MS analysis. The anti-inflammatory effects of ZJP were tested on RAW264.7 macro-phages. ZJP was found to significantly suppress nitric oxide (NO) production and decrease levels of pro-inflammatory cytokines such as COX-2, TNF-alpha, IFN-gamma and IL-17. Molecular profiling showed that ZJP could inhibit phosphorylation of the signaling proteins p-38 and JNK, but not ERIC, revealing ZJP exert anti-inflammatory effects through inhibition of NF-kappa B and p38/JNK MAPK signaling. This study suggests that ZJP can be used to treat inflammatory diseases or as a supplement to health products.
引用
收藏
页码：461 / 470
页数：10
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