Pilot study for family-based association analysis of schizophrenia in a Korean population: Analysis for candidate genes positionally on chromosome 18q21

被引:8
|
作者
Cho, Min Jung [1 ,4 ]
Lee, Byung Dae [2 ,3 ,4 ]
Kim, Choongrak [5 ]
机构
[1] Pusan Natl Univ Hosp, Dept Pediat, Busan 602739, South Korea
[2] Pusan Natl Univ Hosp, Dept Psychiat, Busan 602739, South Korea
[3] Pusan Natl Univ, Coll Med, Dept Psychiat, Kyungnam, South Korea
[4] Pusan Natl Univ Hosp, Med Res Inst, Busan 602739, South Korea
[5] Pusan Natl Univ, Dept Stat, Busan, South Korea
关键词
association; family; genetic; Korean; schizophrenia; BIPOLAR DISORDER; SUSCEPTIBILITY LOCI; GENOME SCAN; DIAGNOSTIC INTERVIEW; LINKAGE; DEPRESSION; COMPLEX; TWIN;
D O I
10.1111/appy.12167
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Introduction: Schizophrenia is the most devastating mental illness that causes severe deterioration in social and occupational functioning. This is a pilot study for family-based association analysis of schizophrenia in a Korean population to search candidate genes functionally relevant and positionally on chromosome 18. Methods: We have recruited 27 probands (with psychosis) with their parents and siblings whenever possible. We analyzed 20 SNPs (Single Nucleotide Polymorphism) of seven neuronal genes in chromosome 18 for DNA samples that was checked for the data quality and genotype error. For testing of association, we performed family-based association tests analyses with each individual SNP, using the phenotype of psychosis. And then, we performed family-based association tests haplotype analyses with each individual SNP, using the phenotype of psychosis. Finally, we performed linkage disequilibrium analyses for the phenotype of schizophrenia. Results: We found one significant SNPs of one neuronal gene in chromosome 18 (P value < 0.05) for the qualitative phenotype of psychosis (rs1893490:MAPK4). We also found significant haplotypes of four SNPs in mitogen-activated protein kinase 4 (MAPK4) gene of chromosome 18 (P value < 0.1) for the phenotype of psychosis (rs1893490-rs3892158-rs3752088-rs3794899). Two SNPS within the MAPK4 gene (rs3794899, rs3794901), plus SNPs within the malic enzyme 2 (rs685533, rs12277), and SMAD4 genes (rs8096092, rs2298617) were in strong linkage disequilibrium with each other (D' > 0.60). Discussion: The present findings provide convergent evidence (fine mapping of a chromosomal locus 18q21 associated with schizophrenia) suggesting that a specific MAPK4 could be a candidate gene for causing a spectrum of schizophrenia phenotype.
引用
收藏
页码:268 / 275
页数:8
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