Dosimetric impact of statistical uncertainty on Monte Carlo dose calculation algorithm in volumetric modulated arc therapy using Monaco TPS for three different clinical cases

Aim To study the dosimetric impact of statistical uncertainty (SU) per plan on Monte Carlo MC) calculation in MonacoTMtreatment planning system (TPS) during volumetric modulated arc therapy (VMAT) for three different clinical cases. Background: During MC calculation SU is an important factor to decide dose calculation accuracy and calculation time. It is necessary to evaluate optimal acceptance of SU for quality plan with reduced calculation time. Materials and methods: Three different clinical cases as the lung, larynx, and prostate treated using VMAT technique were chosen. Plans were generated with MonacoTMV5.11 TPS with 2% statistical uncertainty. By keeping all other parameters constant, plans were recalculated by varying SU, 0.5%, 1%, 2%, 3%, 4%, and 5%. For plan evaluation, conformity index ( CI), homogeneity index (HI), dose coverage to PTV, organ at risk (OAR) dose, normal tissue receiving dose > 5 Gy and >= 10 Gy, integral dose (NTID), calculation time, gamma pass rate, calculation reproducibility and energy dependency were analyzed. Results: CI and HI improve as SU increases from 0.5% to 5%. No significant dose difference was observed in dose coverage to PTV, OAR doses, normal tissue receiving dose >= 5 Gy and >= 10 Gy and NTID. Increase of SU showed decrease in calculation time, gamma pass rate and increase in PTV max dose. No dose difference was seen in calculation reproducibility and dependent on energy. Conclusion: For VMAT plans, SU can be accepted from 1% to 3% per plan with reduced calculation time without compromising plan quality and deliverability by accepting variations inpoint dose within the target. (C) 2019 Greater Poland Cancer Centre. Published by Elsevier B.V. All rights reserved.