Developmental changes in NMDA receptor expression in the platyfish brain

被引：10
|
作者：
Flynn, KM
Schreibman, MP
MagliuloCepriano, L
机构：
[1] CUNY BROOKLYN COLL, DEPT BIOL, BROOKLYN, NY 11210 USA
[2] CUNY, GRAD SCH, NEW YORK, NY USA
[3] CUNY, UNIV CTR, NEW YORK, NY USA
[4] SUNY FARMINGDALE, FARMINGDALE, NY USA
来源：
BRAIN RESEARCH | 1997年 / 771卷 / 01期
基金：
美国国家航空航天局;
关键词：
glutamate; GnRH; aging; hypothalamus; puberty;
D O I：
10.1016/S0006-8993(97)00626-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have examined the distribution of the N-methyl-D-aspartate (NMDA) receptor in the brain of a freshwater teleost using an antibody against the R1 subunit of the receptor (NMDAR1). The primary site of localization was the nucleus olfactoretinalis (NOR), a significant gonadotropin releasing hormone (GnRH)-containing brain nucleus. The number of cells expressing NMDAR1 in this nucleus was dependent upon developmental stage, with pubescent and mature animals displaying significantly more stained cells than immature and senescent animals. This is the First reported observation of age-and maturity-related NMDA receptor association with GnRH-containing brain areas. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：142 / 146
页数：5
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