Regulation of cancer cell survival by Par-4

被引：32
|
作者：
Ranganathan, P
Rangnekar, VM
机构：
[1] Univ Kentucky, Dept Radiat Med, Lexington, KY 40536 USA
[2] Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA
[3] Univ Kentucky, Dept Microbiol & Immunol & Mol Genet, Lexington, KY 40536 USA
[4] Univ Kentucky, Markey Canc Ctr, Lexington, KY 40536 USA
来源：
TUMOR PROGRESSION AND THERAPEUTIC RESISTANCE | 2005年 / 1059卷
关键词：
Par-4; apoptosis; cancer;
D O I：
10.1196/annals.1339.046
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.
引用
收藏
页码：76 / 85
页数：10
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