[18-C-6H3O+]: an in-situ generated macrocyclic complex and an efficient, novel catalyst for synthesis of pyrano[2,3-c]pyrazole derivatives

被引：12

作者：

Mishra, Manisha ^{[1
]}

Jomon, K. J. ^{[1
]}

Krishnan, V. R. Sriram ^{[1
]}

Nizam, Aatika ^{[1
]}

机构：

[1] CHRIST, Dept Chem, Hosur Rd, Bangalore 560029, Karnataka, India

来源：

SCIENTIFIC REPORTS | 2020年 / 10卷 / 01期

关键词：

IONIC LIQUIDS; ONE-POT; CROWN; CATION; PYRAZOLES; WATER;

D O I：

10.1038/s41598-020-70665-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Synthesis of small aromatic heterocycles is of greater importance in the organic chemistry due to their vibrant applications in pharmaceuticals, agrochemicals and veterinary products. Pyranopyrazoles are one such class of heterocycles associated with numerous applications. Hence herein we report a multicomponent crown ether catalyzed, ultrasound irradiated methodology to make different functionalized pyranopyrazoles in a single step. This technique involves the in-situ generation of [18-C-6H(3)O(+)][OH-] complex, which in turn activates the aromatic aldehyde and aids in the facile nucleophilic addition.

引用

页数：6

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