Copper-Catalyzed C-H Fluorination/Functionalization Sequence Enabling Benzylic C-H Cross Coupling with Diverse Nucleophiles

被引：75

作者：

Vasilopoulos, Aristidis ^{[1
]}

Golden, Dung L. ^{[1
]}

Buss, Joshua A. ^{[1
]}

Stahl, Shannon S. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, 1101 Univ Ave, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 15期

关键词：

BONDS; ACTIVATION; AMINATION; FUNCTIONALIZATION;

D O I：

10.1021/acs.orglett.0c02238

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Site-selective transformation of benzylic C-H bonds into diverse functional groups is achieved via Cu-catalyzed C-H fluorination with N-fluorobenzenesulfonimide (NFSI), followed by substitution of the resulting fluoride with various nucleophiles. The benzyl fluorides generated in these reactions are reactive electrophiles in the presence of hydrogen-bond donors or Lewis acids, allowing them to be used without isolation in C-O, C-N, and C-C coupling reactions.

引用

页码：5753 / 5757

页数：5

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