Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferase

被引：56

作者：

Rackham, Mark D. ^{[1
]}

Brannigan, James A. ^{[2
]}

Moss, David K. ^{[3
]}

Yu, Zhiyong ^{[1
]}

Wilkinson, Anthony J. ^{[2
]}

Holder, Anthony A. ^{[3
]}

Tate, Edward W. ^{[1
]}

Leatherbarrow, Robin J. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

[2] Univ York, Dept Chem, York Struct Biol Lab, York YO10 5DD, N Yorkshire, England

[3] MRC Natl Inst Med Res, Div Parasitol, London NW7 1AA, England

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 56卷 / 01期

基金：

英国医学研究理事会; 英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

DESIGN;

D O I：

10.1021/jm301474t

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

N-Myristoyltransferase (NMT) is an attractive antiprotozoan drug target. A lead-hopping approach was utilized in the design and synthesis of novel benzo[b]thiophene-containing inhibitors of Plasmodium falciparum (PO and Plasmodium vivax (Pv) NMT. These inhibitors are selective against Homo sapiens NMT1 (HsNMT), have excellent ligand efficiency (LE), and display antiparasitic activity in vitro. The binding mode of this series was determined by crystallography and shows a novel binding mode for the benzothiophene ring.

引用

页码：371 / 375

页数：5

共 50 条

[31] Exploring Novel N-Myristoyltransferase Inhibitors: A Molecular Dynamics Simulation Approach
Khalil, Ruciaiya
Ashraf, Sajda
Khalid, Asaad
Ul-Haq, Zaheer
ACS OMEGA, 2019, 4 (09): : 13658 - 13670
[32] Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase
Devadas, B
Freeman, SK
McWherter, CA
Kishore, NS
Lodge, JK
Jackson-Machelski, E
Gordon, JI
Sikorski, JA
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (06) : 996 - 1000
[33] Novel inhibitors of the Plasmodium falciparum electron transport chain
Stocks, P. A.
Barton, V.
Antoine, T.
Biagini, G. A.
Ward, S. A.
O'Neill, P. M.
PARASITOLOGY, 2014, 141 (01) : 50 - 65
[34] Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode
Spinks, Daniel
Smith, Victoria
Thompson, Stephen
Robinson, David A.
Luksch, Torsten
Smith, Alasdair
Torrie, Leah S.
McElroy, Stuart
Stojanovski, Laste
Norval, Suzanne
Collie, Iain T.
Hallyburton, Irene
Rao, Bhavya
Brand, Stephen
Brenk, Ruth
Frearson, Julie A.
Read, Kevin D.
Wyatt, Paul G.
Gilbert, Ian H.
CHEMMEDCHEM, 2015, 10 (11) : 1821 - 1836
[35] Novel Baicalein-Derived Inhibitors of Plasmodium falciparum
Gudla, Chandra Sekhar
Selvam, Vignesh
Selvaraj, Siva Shanmugam
Tripathi, Renu
Joshi, Prince
Shaham, Salique Hassan
Singh, Mayas
Shandil, Radha Krishan
Habib, Saman
Narayanan, Shridhar
PATHOGENS, 2023, 12 (10):
[36] Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes
Balasubramanian, Sujata
Rahman, Rifat S.
Lon, Chanthap
Parobek, Christian
Ubalee, Ratawan
Hathaway, Nicholas
Kuntawunginn, Worachet
My, Mok
Vy, Dav
Saxe, Jeremy
Lanteri, Charlotte
Lin, Feng-Chang
Spring, Michele
Meshnick, Steven R.
Juliano, Jonathan J.
Saunders, David L.
Lin, Jessica T.
JOURNAL OF INFECTIOUS DISEASES, 2020, 221 (03): : 428 - 437
[37] Discovery of triazolopyrimidine-based PDE8B inhibitors: Exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes
DeNinno, Michael P.
Wright, Stephen W.
Etienne, John B.
Olson, Thanh V.
Rocke, Benjamin N.
Corbett, Jeffrey W.
Kung, Daniel W.
DiRico, Kenneth J.
Andrews, Kim M.
Millham, Michele L.
Parker, Janice C.
Esler, William
van Volkenburg, Maria
Boyer, David D.
Houseknecht, Karen L.
Doran, Shawn D.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (17) : 5721 - 5726
[38] Discovery of Novel Myristic Acid Derivatives as N-Myristoyltransferase Inhibitors: Design, Synthesis, Analysis, Computational Studies and Antifungal Activity
Javid, Saleem
Ather, Hissana
Hani, Umme
Siddiqua, Ayesha
Ansari, Shaik Mohammad Asif
Shanmugarajan, Dhivya
Kumar, Honnavalli Yogish
Arivuselvam, Rajaguru
Purohit, Madhusudan N.
Kumar, B. R. Prashantha
ANTIBIOTICS-BASEL, 2023, 12 (07):
[39] Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase
Kaur, Supreet
Nieto, Nicholas S.
McDonald, Peter
Beck, Josh R.
Honzatko, Richard B.
Roy, Anuradha
Nelson, Scott W.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 37 (01) : 1320 - 1326
[40] ANTIGEN DISCOVERY OF NOVEL SEROLOGICAL MARKERS OF RECENT PLASMODIUM VIVAX INFECTION
Suen, Connie S. Li Wai
Takashima, Eizo
Proietti, Carla
Longley, Rhea
Robinson, Leanne J.
Franca, Camila
Betuela, Inoni
Kuehn, Andrea
Morita, Masayuki
Smyth, Gordon
Xavier, Ding
Siba, Peter M.
Gonzalez, Iveth J.
Lacerda, Marcus
Sattabongkot, Jetsumon
Doolan, Denise
Tsuboi, Takafumi
Mueller, Ivo
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2015, 93 (04): : 252 - 252

← 1 2 3 4 5 →