Point-of-care testing of neonatal coagulation

被引：8
|
作者：
Tan, K
Booth, D
Newell, SJ
Dear, PRF
Hughes, C
Richards, M
机构：
[1] St Jamess Univ Hosp, Neonatol Unit, Leeds, W Yorkshire, England
[2] St Jamess Univ Hosp, Dept Paediat Haematol & Oncol, Leeds, W Yorkshire, England
来源：
CLINICAL AND LABORATORY HAEMATOLOGY | 2006年 / 28卷 / 02期
关键词：
coagulation; point-of-care testing; neonatal; validation study;
D O I：
10.1111/j.1365-2257.2006.00765.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this validation study was to compare prothrombin time (PT) and activated partial thromboplastin time (APTT) results from a point-of-care testing (POCT) device (Rapidpoint Coag) with those from standard laboratory tests. The subjects were newborn infants needing coagulation screen for any clinical indications within a regional neonatal intensive care unit. The level of agreement between POCT and laboratory measurements of PT and APTT was determined. For PT: the bias was from -7.6 to 12.4 s and precision was 5.0 s. For the detection of prolonged PT at a level of 16 s, the sensitivity was 0.70, specificity was 0.57 and the positive predictive value (PPV) was 0.62. For APTT: the bias was from -39.1 to 23.7 s, and precision was 15.7 s. For the detection of prolonged APTT at a level of 55 s, the sensitivity was 0.80, specificity was 0.95 and the PPV was 0.80. The POCT device tested has limited utility as a cot-side device for screening for a prolongation of the APTT in the newborn but is not sensitive for screening for prolongation of the PT.
引用
收藏
页码：117 / 121
页数：5
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