Propofol Anesthesia Impairs the Maturation and Survival of Adult-born Hippocampal Neurons

被引:67
|
作者
Krzisch, Marine [1 ]
Sultan, Sebastien [1 ]
Sandell, Julie [1 ]
Demeter, Kornel [1 ]
Vutskits, Laszlo [1 ]
Toni, Nicolas [1 ]
机构
[1] Univ Lausanne, Dept Fundamental Neurosci, CH-1005 Lausanne, Switzerland
基金
瑞士国家科学基金会;
关键词
ENHANCED SYNAPTIC PLASTICITY; MEDIAL PREFRONTAL CORTEX; NITROUS OXIDE ANESTHESIA; NEWLY GENERATED NEURONS; DENTATE GYRUS; AGED RATS; CRITICAL PERIOD; SPATIAL MEMORY; ALZHEIMERS-DISEASE; NEUROGENESIS;
D O I
10.1097/ALN.0b013e3182815948
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: Adult neurogenesis occurs in the hippocampus of most mammals, including humans, and plays an important role in hippocampal-dependent learning. This process is highly regulated by neuronal activity and might therefore be vulnerable to anesthesia. In this article, the authors investigated this possibility by evaluating the impact of propofol anesthesia on mouse hippocampal neurons generated during adulthood, at two functionally distinct maturational stages of their development. Methods: Adult-born hippocampal neurons were identified using the cell proliferation marker bromodeoxyuridine or a retroviral vector expressing the green fluorescent protein in dividing cells and their progenies. Eleven or 17 days after the labeling procedure, animals (n = 3-5 animals per group) underwent a 6-h-long propofol anesthesia. Twenty-one days after labeling, the authors analyzed the survival, differentiation, and morphologic maturation of adult-born neurons using confocal microscopy. Results: Propofol impaired the survival and maturation of adult-born neurons in an age-dependent manner. Anesthesia induced a significant decrease in the survival of neurons that were 17 days old at the time of anesthesia, but not of neurons that were 11 days old. Similarly, propofol anesthesia significantly reduced the dendritic maturation of neurons generated 17 days before anesthesia, without interfering with the maturation of neurons generated 11 days before anesthesia. Conclusions: These results reveal that propofol impairs the survival and maturation of adult-born hippocampal neurons in a developmental stage-dependent manner in mice.
引用
收藏
页码:602 / 610
页数:9
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