Response of Isolated Rat Heart to α2-Adrenergic Receptor Stimulation after If Current Blockade in the Late Postinfarction Period

被引：0

作者：

Bugrov, R. K. ^{[1
]}

Kuptsova, A. M. ^{[1
]}

Ziyatdinova, N., I ^{[1
]}

Zefrov, T. L. ^{[1
]}

机构：

[1] Kazan Volga Reg State Univ, Dept Human Hlth Protect, Kazan, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2022年 / 174卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

alpha(2)-adrenergic receptors; I-f-currents; myocardial infarction model; isolated heart; rat; INJURY;

D O I：

10.1007/s10517-022-05640-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of alpha(2)-adrenoreceptor activation after preliminary I-f -current blockade on the performance of the Langendorff-isolated rat heart 54 days after modeling myocardial infarction. Stimulation of alpha(2)-adrenoreceptors against the background of application of I-f blocker ZD7288 in concentrations of 10(-9) and 10(-5) M decreased myocardial inotropy in isolated rat hearts by 50 and 39% (p<0.05) and increased HR by 20 and 15% (p<0.05), respectively. Activation of alpha(2)-adrenoreceptors against the background of application of ZD7288 in a concentration of 10(-9) and 10(-5) M led to a decrease in the coronary flow in the isolated rat heart with the model of myocardial infarction by 21% (p<0.05) and 32% (p<0.05), respectively.

引用

页码：22 / 25

页数：4

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