Rational Design of Neutral Allosteric Modulators of the CB1 Receptor with Improved Receptor Interactions and Unique Pharmacology

被引:0
|
作者
Shore, Derek M. [1 ]
Hurst, Dow P. [1 ]
Navas, Frank J. [2 ]
Seltzman, Herbert H. [2 ]
Baillie, Gemma L. [3 ]
Ross, Ruth A. [3 ]
Reggio, Patricia H. [1 ]
机构
[1] UNC Greensboro, Ctr Drug Discovery, Greensboro, NC USA
[2] Res Triangle Inst, Res Triangle Pk, NC 27709 USA
[3] Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland
关键词
D O I
10.1016/j.bpj.2012.11.2278
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:408A / 409A
页数:2
相关论文
共 50 条
  • [21] Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1
    Yang, Xin
    Wang, Xuehui
    Xu, Zheng
    Wu, Chao
    Zhou, Yangli
    Wang, Yifei
    Lin, Guifeng
    Li, Kan
    Wu, Ming
    Xia, Anjie
    Liu, Jingming
    Cheng, Lin
    Zou, Jun
    Yan, Wei
    Shao, Zhenhua
    Yang, Shengyong
    NATURE CHEMICAL BIOLOGY, 2022, 18 (08) : 831 - +
  • [22] The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators
    Tseng, Chih-Chung
    Baillie, Gemma
    Donvito, Giulia
    Mustafa, Mohammed A.
    Juola, Sophie E.
    Zanato, Chiara
    Massarenti, Chiara
    Dall'Angelo, Sergio
    Harrison, William T. A.
    Lichtman, Aron H.
    Ross, Ruth A.
    Zanda, Matteo
    Greig, Iain R.
    JOURNAL OF MEDICINAL CHEMISTRY, 2019, 62 (10) : 5049 - 5062
  • [23] Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor
    Laprairie, R. B.
    Bagher, A. M.
    Kelly, M. E. M.
    Denovan-Wright, E. M.
    BRITISH JOURNAL OF PHARMACOLOGY, 2015, 172 (20) : 4790 - 4805
  • [24] Identification of an allosteric binding site at the cannabinoid CB1 receptor
    Barber, Teresa S.
    Hurst, Dow P.
    Reggio, Patricia H.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [25] Toward the Design of Cannabinoid CB1 Receptor Inverse Agonists and Neutral Antagonists
    Reggio, Patricia H.
    DRUG DEVELOPMENT RESEARCH, 2009, 70 (08) : 585 - 600
  • [26] Towards rational design of cannabinoid receptor 1 (CB1) antagonists for peripheral selectivity
    Fulp, Alan
    Bortoff, Katherine
    Zhang, Yanan
    Seltzman, Herbert
    Snyder, Rodney
    Maitra, Rangan
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (19) : 5711 - 5714
  • [27] Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor
    Saleh, Noureldin
    Hucke, Oliver
    Kramer, Gert
    Schmidt, Esther
    Montel, Florian
    Lipinski, Radoslaw
    Ferger, Boris
    Clark, Timothy
    Hildebrand, Peter W.
    Tautermann, Christofer S.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (10) : 2580 - 2585
  • [28] Trifluoromethyl group as a bioisosteric replacement of aliphatic nitro group in CB1 receptor positive allosteric modulators (PAMs)
    Zanda, Matteo
    Greig, Iain
    Tseng, Chih-Chung
    Ross, Ruth
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [29] Rational drug design of potent agonists and antagonists for the CB1 cannabinoid receptor.
    Shim, JY
    Collantes, ER
    Welsh, WJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 77 - COMP
  • [30] Cannabinoid 1 (CB1) Receptor - Pharmacology, Role in Pain and Recent Developments in Emerging CB1 Agonists
    Talwar, Rashmi
    Potluri, Vijay Kumar
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2011, 10 (05) : 536 - 544