Tailored Glycopolymers as Anticoagulant Heparin Mimetics

被引：86
|
作者：
Oh, Young In [1 ,2 ]
Sheng, Gloria J. [1 ,2 ]
Chang, Shuh-Kuen [3 ]
Hsieh-Wilson, Linda C. [1 ,2 ]
机构：
[1] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA
[2] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA
[3] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 45期
基金：
美国国家卫生研究院;
关键词：
anticoagulant; biomimetic synthesis; drug discovery; glycopolymers; heparin; MOLECULAR-WEIGHT HEPARIN; CHONDROITIN SULFATE; HIGH-AFFINITY; ANTITHROMBIN; PENTASACCHARIDE; OLIGOSACCHARIDES; GENERATION; LIGANDS; BINDING; PROBES;
D O I：
10.1002/anie.201306968
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Not to clot: Heparin and its low-molecular-weight derivatives are clinical therapeutics used to treat and prevent blood clots. The synthesis of heparin-based glycopolymers that are potent and potentially safer mimetics of heparin is described. The mimetics exhibited activity against proteases (FXa and FIIa) in the coagulation cascade and prolonged blood clot times in human plasma with efficacies similar to those of clinical anticoagulants. ATIII=antithrombin-III. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11796 / 11799
页数：4
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