Cellular functions of long noncoding RNAs

被引：1104
|
作者：
Yao, Run-Wen [1 ]
Wang, Yang [1 ]
Chen, Ling-Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Univ Chinese Acad Sci, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Shanghai, Peoples R China
[2] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
来源：
NATURE CELL BIOLOGY | 2019年 / 21卷 / 05期
基金：
中国国家自然科学基金;
关键词：
MESSENGER-RNAS; GENE-EXPRESSION; NUCLEAR-BODIES; X-CHROMOSOME; XIST RNA; ANTISENSE TRANSCRIPTION; CHROMATIN INTERACTIONS; COLORECTAL-CANCER; CERNA HYPOTHESIS; BINDING PROTEINS;
D O I：
10.1038/s41556-019-0311-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.
引用
收藏
页码：542 / 551
页数：10
相关论文
共 50 条
  • [21] The functions of long noncoding RNAs in development and stem cells
    Perry, Rotem Ben-Tov
    Ulitsky, Igor
    DEVELOPMENT, 2016, 143 (21): : 3882 - 3894
  • [22] Long Noncoding RNAs: Molecular Modalities to Organismal Functions
    Rinn, John L.
    Chang, Howard Y.
    ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89, 2020, 89 : 283 - 308
  • [23] Functions and mechanisms of long noncoding RNAs in lung cancer
    Peng, Zhenzi
    Zhang, Chunfang
    Duan, Chaojun
    ONCOTARGETS AND THERAPY, 2016, 9 : 4411 - 4424
  • [24] Transcriptional kinetics and molecular functions of long noncoding RNAs
    Johnsson, Per
    Ziegenhain, Christoph
    Hartmanis, Leonard
    Hendriks, Gert-Jan
    Hagemann-Jensen, Michael
    Reinius, Bjorn
    Sandberg, Rickard
    NATURE GENETICS, 2022, 54 (03) : 306 - +
  • [25] Long Noncoding RNAs: Cellular Address Codes in Development and Disease
    Batista, Pedro J.
    Chang, Howard Y.
    CELL, 2013, 152 (06) : 1298 - 1307
  • [26] lncRedibly versatile: biochemical and biological functions of long noncoding RNAs
    Shields, Emily J.
    Petracovici, Ana F.
    Bonasio, Roberto
    BIOCHEMICAL JOURNAL, 2019, 476 : 1083 - 1104
  • [27] Long noncoding RNAs coordinate functions between mitochondria and the nucleus
    Dong, Yaru
    Yoshitomi, Takeshi
    Hu, Ji-Fan
    Cui, Jizhe
    EPIGENETICS & CHROMATIN, 2017, 10
  • [28] Long noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms
    Wang, Xu
    Zhang, Jing
    Liu, Xiaojing
    Wei, Bing
    Zhan, Lei
    JOURNAL OF CELLULAR PHYSIOLOGY, 2021, 236 (01) : 6 - 14
  • [29] Long noncoding RNAs in gastric cancer: functions and clinical applications
    Wang, Jiajun
    Sun, Jingxu
    Wang, Jun
    Song, Yongxi
    Gao, Peng
    Shi, Jinxin
    Chen, Ping
    Wang, Zhenning
    ONCOTARGETS AND THERAPY, 2016, 9 : 681 - 697
  • [30] Elucidating broad functions of long noncoding RNAs in human cells
    Ramilowski, Jordan
    Agrawal, Saumya
    Yip, Chi-Wai
    Hon, Chung Chau
    Ito, Masayoshi
    Kasukawa, Takeya
    Kondo, Naoto
    Yagi, Ken
    Suzuki, Harukazu
    Shin, Jay W.
    de Hoon, Michiel
    Carninci, Piero
    HUMAN GENOMICS, 2018, 12
12345