Risk factors for acquisition of Pseudomonas aeruginosa in a surgical intensive care unit

Objectives To investigate the risk factors for the acquisition (infection and/or colonization) of Pseudomonas aeruginosa, which is frequently associated with nosocomial infections, in a surgical intensive care unit in Dijon. Method A retrospective case-control study was performed on 57 cases matching with 114 controls, between December 1996 and February 1999. The statistical method used was a conditional multiple logistic regression model. Results Three groups of variables were studied (patient characteristics-invasive procedures-previous administration of antibiotics). The multiple logistic regression analysis confirmed 3 risk factors: duration of sedation, infection with another bacteria and cranio-encephalic trauma. These factors are commonly involved in nosocomial infections. Conclusion This study confirms the interest of infection control measures and the prevention of nosocomial infections, especially in cranio-encephalic trauma. The hypothetical relationship between acquisition of Pseudomonas aeruginosa and previous administration of antibiotics was not confirmed, A more powerful study would perhaps specify this relationship. (C) Masson, Paris.