Zn2+ differentially modulates kinetics of GABAC vs GABAA receptors in carp retinal bipolar cells

被引：20
|
作者：
Han, MH
Yang, XL
机构：
[1] Chinese Acad Sci, Shanghai Inst Physiol, Shanghai 200031, Peoples R China
[2] Chinese Acad Sci, Key Lab Neurobiol, Shanghai 200031, Peoples R China
来源：
NEUROREPORT | 1999年 / 10卷 / 12期
关键词：
activation; deactivation; desensitization; GABA(A) receptor; GABA(C) receptor; kinetics; zinc;
D O I：
10.1097/00001756-199908200-00028
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
GABA(C) and GABA(A) receptors co-exist in retinal bipolar cells. In the present study the effects of zinc on the kinetics of currents mediated by GABA(C) and GABA(A) receptors were investigated in isolated carp bipolar cells, using whole-cell patch-clamp technique. We observed for the first time that zinc exerted opposite effects on kinetics of the GABA(C) and GABA(A) responses: zinc significantly slowed down activation and desensitization of the GABA(C) response, but accelerated those of the GABA(A) response; zinc dramatically accelerated deactivation of the GABA(C) response, whereas it had no apparent effect on deactivation of the GABA(A) response. These results suggest that zinc may be functionally important in regulating retinal signal transmission. (C) 1999 Lippincott Williams & Wilkins.
引用
收藏
页码：2593 / 2597
页数：5
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