An Efficient Route to 3-Amidylindoles via a Palladium- Catalyzed Tandem Reaction of 2-Alkynylanilines with Isocyanides

被引：53
|
作者：
Qiu, Guanyinsheng [1 ]
Chen, Chen [2 ]
Yao, Liangqing [2 ]
Wu, Jie [1 ,3 ]
机构：
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Fudan Univ, Obstet & Gynecol Hosp, 419 Fangxie Rd, Shanghai 200011, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 08期
基金：
中国国家自然科学基金;
关键词：
3-amidylindoles; N; N-dimethyl-2-alkynylanilines; isocyanides; palladium catalyst; tandem reactions; FUNCTIONALIZED INDOLES; 3-COMPONENT REACTION; CASCADE REACTIONS; ARYL HALIDES; INSERTION; ALKYNES; HETEROCYCLES; CONSTRUCTION; CYCLIZATION; ACTIVATION;
D O I：
10.1002/adsc.201300198
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A palladium-catalyzed reaction of 2-alkynylaniline, isocyanides, and silver acetate is described, leading to 3-amidylindoles in moderate to good yields. During the process, five new bonds are formed with high reaction efficiency in one-pot procedure.
引用
收藏
页码：1579 / 1584
页数：6
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