Effects of tetrandrine on changes of NMDA receptor channel in cortical neurons of rat induced by anoxia

被引：0
|
作者：
Wang, ZF
Xue, CS
Zhou, QX
Wan, ZB
Luo, QS
机构：
[1] Chongqing Univ Med Sci, Dept Pharmacol, Chongqing 400046, Peoples R China
[2] Third Mil Med Univ, Dept Physiol, Chongqing 400038, Peoples R China
来源：
ACTA PHARMACOLOGICA SINICA | 1999年 / 20卷 / 08期
关键词：
tetrandrine; N-methyl-D-aspartate receptors; ion channels; patch-clamp techniques; cerebral cortex; anoxia; dizocilpine maleate;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AIM: To study the effects of tetrandrine (Tet) on the changes of NMDA receptor channels in cortical neurons induced by anoxia. METHODS: Cell-attached configuration of patch-clamp techniques. Anoxia was produced by perfused cells with 95 % N-2 + 5 % CO2 gassed bath solution. RESULTS: During anoxia, the open time constant (tau(2)), open probability (P-o) of 35-pS and 100-pS channels increased. Tet 7.5 mu mol.L-1 reduced the P-o of 35-pS and 100-pS channels, 15 and 30 mu mol.L-1 inhibited open of 100-pS channel fully, and changed the open time constant of 35-pS from two to single exponential distribution. CONCLUSION: Tet inhibition of the open of NMDA receptor channels induced by anoxia was one of its protective mechanisms.
引用
收藏
页码：729 / 732
页数：4
相关论文
共 50 条
  • [41] Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons
    Pamenter, Matthew Edward
    Shin, Damian Seung-Ho
    Buck, Leslie Thomas
    BRAIN RESEARCH, 2008, 1213 : 27 - 34
  • [42] NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue
    André, VM
    Flores-Hernández, J
    Cepeda, C
    Starling, AJ
    Nguyen, S
    Lobo, MK
    Vinters, HV
    Levine, MS
    Mathern, GW
    CEREBRAL CORTEX, 2004, 14 (06) : 634 - 646
  • [43] Halothane modulates NMDA and non-NMDA excitatory synaptic transmission in rat cortical neurons
    Kitamura A.
    Satoh R.
    Nagano T.
    Matsuda H.
    Shimizu T.
    Sakamoto A.
    Ogawa R.
    Journal of Anesthesia, 2005, 19 (1) : 66 - 72
  • [44] Mechanisms of ammonia-induced cell death in rat cortical neurons: Roles of NMDA receptors and glutathione
    Klejman, A
    Wegrzynowicz, M
    Szatmari, EM
    Mioduszewska, B
    Hetman, M
    Albrecht, J
    NEUROCHEMISTRY INTERNATIONAL, 2005, 47 (1-2) : 51 - 57
  • [45] Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons
    Jaekel, B
    Mühlberg, K
    de Arriba, GS
    Reichenbach, A
    Verdaguer, E
    Pallas, M
    Camins, A
    Nörenberg, W
    Allgaier, C
    JOURNAL OF NEUROCHEMISTRY, 2005, 94 : 53 - 54
  • [46] Neuroprotection associated with alternative splicing of NMDA receptors in rat cortical neurons
    Jaekel, B
    Mühlberg, K
    de Arriba, SG
    Reichenbach, A
    Verdaguer, E
    Pallas, M
    Camins, A
    Nörenberg, W
    Allgaier, C
    BRITISH JOURNAL OF PHARMACOLOGY, 2006, 147 (06) : 622 - 633
  • [47] Role of Ca2+ in NMDA receptor regulation in cortical neurons of the anoxia-tolerant western painted turtle (Chrysemys picta bellii)
    Pamenter, M
    Shin, D
    Buck, L
    FASEB JOURNAL, 2005, 19 (04): : A214 - A214
  • [48] Molecular mechanisms of action determine inhibition of paroxysmal depolarizing shifts by NMDA receptor antagonists in rat cortical neurons
    Nikolaev, Maxim, V
    Chizhov, Anton, V
    Tikhonov, Denis B.
    NEUROPHARMACOLOGY, 2021, 184
  • [49] Trichlorethanol impairs NMDA receptor function in rat cortical neurones
    Kronfeld, A
    Müller, D
    Mühlberg, K
    Scheibler, P
    Illes, P
    Allgaier, C
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (04) : R782 - R782
  • [50] Does halothane change NMDA channel open probability in turtle cortical neurons?
    Eilers, H
    Buck, LT
    Bickler, PE
    ANESTHESIA AND ANALGESIA, 1997, 84 : S479 - S479
12345