Mycophenolate Mofetil-related Pancolitis in a Kidney Transplant Recipient

被引：7
|
作者：
Hamouda, Mouna [1 ,3 ]
Mahmoudi, Houda [2 ,3 ]
Skhiri, Habib [1 ,3 ]
Elmay, Mezri [1 ,3 ]
机构：
[1] Fattouma Bourguiba Hosp, Dept Nephrol, Monastir 5000, Tunisia
[2] Fattouma Bourguiba Hosp, Dept Pathol, Monastir 5000, Tunisia
[3] Univ Fac Med, Monastir, Tunisia
来源：
EXPERIMENTAL AND CLINICAL TRANSPLANTATION | 2012年 / 10卷 / 05期
关键词：
Immunosuppression; Colitis; Diarrhea; Kidney transplant; VERSUS-HOST-DISEASE; GASTROINTESTINAL MUCOSAL INJURY; EC-MPS; EXPOSURE; SODIUM; ACID; COMBINATION; PATTERNS;
D O I：
10.6002/ect.2011.0200
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Gastrointestinal adverse effects are common with mycophenolate mofetil administration, especially diarrhea. We report a case of mycophenolate mofetil-related colitis in a kidney transplant recipient. Colonoscopy revealed an ulcerative diffuse colitis. The colonoscopic biopsy specimen showed mild crypt distortion, accompanied by cryptitis and focal graft-versus-host disease like changes. The patient's symptoms improved after we discontinued the mycophenolate mofetil. A repeat colonoscopy 2 months after we discontinued the mycophenolate mofetil showed reparative changes. Mycophenolate mofetil is an important drug in organ transplant immune-suppression regimens; however, with its widespread use, additional adverse effects continue to be recognized.
引用
收藏
页码：501 / 505
页数：5
相关论文
共 50 条
  • [21] Mycophenolate Mofetil-Related Enterocolitis and Weight Loss: A Pediatric Case Series
    Dykes, Dana M. H.
    Moore, Sean R.
    Polk, D. Brent
    Rosen, Michael J.
    Wills, Marcia L.
    Morris, Brian
    Maclin, Jeanine S.
    Nogueira, Janaina
    Katz, Avi
    Hunley, Tracey E.
    Pugh, Judith
    Saeed, Shehzad
    CASE REPORTS IN PEDIATRICS, 2012, 2012
  • [22] Preventing sensitization with mycophenolate mofetil in a pediatric kidney recipient
    Wong, H
    LaBerge, R
    Harvey, E
    Filler, G
    PEDIATRIC TRANSPLANTATION, 2006, 10 (03) : 367 - 370
  • [23] SLCO1B3 T334G polymorphisms and mycophenolate mofetil-related adverse reactions in kidney transplant recipients
    Zhong, Jianxun
    Yang, Kun
    Zhang, Mi
    Wu, Jianhua
    Liu, Liang
    PHARMACOGENOMICS, 2023, 24 (02) : 83 - 91
  • [24] Mycophenolate mofetil/mycophenolate sodiumAcute inflammatory syndrome in a transplant recipient: case report
    Reactions Weekly, 2011, 1373 (1) : 23 - 23
  • [25] Mycophenolate mofetil overdoseLeucopenia in a renal transplant recipient: case report
    Reactions Weekly, 2009, 1235 (1) : 26 - 26
  • [26] Nocardial infection in a renal transplant recipient on tacrolimus and mycophenolate mofetil
    Magee, CC
    Halligan, RD
    Milford, EL
    Sayegh, MH
    CLINICAL NEPHROLOGY, 1999, 52 (01) : 44 - 46
  • [27] Mycophenolate mofetil-induced agranulocytosis in a renal transplant recipient
    Matsui, Katsuomi
    Shibagaki, Yugo
    Sasaki, Hideo
    Chikaraishi, Tatsuya
    Yasuda, Takashi
    Kimura, Kenjiro
    CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2010, 14 (06) : 637 - 640
  • [28] Mycophenolate mofetil-induced agranulocytosis in a renal transplant recipient
    Katsuomi Matsui
    Yugo Shibagaki
    Hideo Sasaki
    Tatsuya Chikaraishi
    Takashi Yasuda
    Kenjiro Kimura
    Clinical and Experimental Nephrology, 2010, 14 : 637 - 640
  • [29] The Cost of Gastrointestinal Adverse Events and the Impact of Dose-Reductions/Discontinuations on Acute Rejection in Kidney Transplant Patients of Mycophenolate Mofetil-Related Compared to Enteric Coated Mycophenolate Sodium: A Pharmacoeconomic Study
    Martinez-Mier, G.
    Salazar-Ramirez, A.
    TRANSPLANTATION PROCEEDINGS, 2016, 48 (02) : 588 - 595
  • [30] Withdrawing mycophenolate mofetil in treating a young kidney transplant recipient with COVID-19 A case report
    Chen, Dong
    Yang, Bo
    Zhang, Yan
    Chen, Liang
    Wei, Lai
    Zhang, Weijie
    Wang, Xinqiang
    Tong, Xiaolin
    Chen, Zhishui
    MEDICINE, 2020, 99 (24) : E20481
12345