Mycophenolate Mofetil-related Pancolitis in a Kidney Transplant Recipient

被引：7

作者：

Hamouda, Mouna ^{[1
,3
]}

Mahmoudi, Houda ^{[2
,3
]}

Skhiri, Habib ^{[1
,3
]}

Elmay, Mezri ^{[1
,3
]}

机构：

[1] Fattouma Bourguiba Hosp, Dept Nephrol, Monastir 5000, Tunisia

[2] Fattouma Bourguiba Hosp, Dept Pathol, Monastir 5000, Tunisia

[3] Univ Fac Med, Monastir, Tunisia

来源：

EXPERIMENTAL AND CLINICAL TRANSPLANTATION | 2012年 / 10卷 / 05期

关键词：

Immunosuppression; Colitis; Diarrhea; Kidney transplant; VERSUS-HOST-DISEASE; GASTROINTESTINAL MUCOSAL INJURY; EC-MPS; EXPOSURE; SODIUM; ACID; COMBINATION; PATTERNS;

D O I：

10.6002/ect.2011.0200

中图分类号：

R3 [基础医学]; R4 [临床医学];

学科分类号：

1001 ; 1002 ; 100602 ;

摘要：

Gastrointestinal adverse effects are common with mycophenolate mofetil administration, especially diarrhea. We report a case of mycophenolate mofetil-related colitis in a kidney transplant recipient. Colonoscopy revealed an ulcerative diffuse colitis. The colonoscopic biopsy specimen showed mild crypt distortion, accompanied by cryptitis and focal graft-versus-host disease like changes. The patient's symptoms improved after we discontinued the mycophenolate mofetil. A repeat colonoscopy 2 months after we discontinued the mycophenolate mofetil showed reparative changes. Mycophenolate mofetil is an important drug in organ transplant immune-suppression regimens; however, with its widespread use, additional adverse effects continue to be recognized.

引用

页码：501 / 505

页数：5

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