Antioxidant and Anti-cholinesterase Activity of Globularia meridionalis Extracts and Isolated Constituents

被引：0
|
作者：
Tundis, Rosa [1 ]
Bonesi, Marco [1 ]
Menichini, Federica [1 ]
Loizzo, Monica R. [1 ]
Conforti, Filomena [1 ]
Statti, Giancarlo [1 ]
Pirisi, Filippo M. [2 ]
Menichini, Francesco [1 ]
机构：
[1] Univ Calabria, Dept Pharmaceut Sci, Fac Pharm & Nutr & Hlth Sci, I-87030 Arcavacata Di Rende, CS, Italy
[2] Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy
来源：
NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 08期
关键词：
Globularia meridionalis; Flavonoids; Phenylethanoids; Antioxidant activity; Anti-cholinesterase activity; IRIDOID GLYCOSIDES; ACETYLCHOLINESTERASE; FLAVONOIDS; INHIBITORS; ACTEOSIDE; CELLS; L;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The antioxidant and anti-cholinesterase properties of Globularia meridionalis (Podp.) O. Schwarz (Globulariaceae) were investigated. G. meridionalis aerial parts aid roots were extracted with methanol, and the total extract successively partitioned with n-hexane. The methanol fraction of the roots showed the highest antioxidant activity with IC50 values of 8.0 and 2.1 mu g/mL in the DPPH and beta-carotene bleaching tests, respectively. From this fraction, three flavonoids, namely pectolinarigenin 7-O-beta-glucoside, apigenin 7-O-beta-glucoside and luteolin, and two phenylethanoids, namely acteoside and isoacteoside, were isolated. Potential anti-cholinesterase effects were assessed through the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibition assay. The n-hexane fraction of the roots exhibited the highest activity against both AChE and BChE with IC50 values of 65.5 and 70.4 mu g/mL, respectively.
引用
收藏
页码：1015 / 1020
页数：6
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