Eradication of gastric Helicobacter spp. by triple therapy in dogs

被引：7
|
作者：
Mirzaeian, S. [1 ]
Sarchahi, A. A. [2 ]
Tabrizi, A. Shojaee [1 ]
Derakhshandeh, A. [1 ]
机构：
[1] Shiraz Univ, Fac Vet Med, Shiraz, Iran
[2] Ferdowsi Univ Mashhad, Fac Vet Med, Mashhad, Iran
来源：
VETERINARNI MEDICINA | 2013年 / 58卷 / 11期
关键词：
Helicobacter spp; dog; amoxicillin; clarithromycin; omeprazole; PROTON PUMP INHIBITOR; PYLORI; HEILMANNII; METAANALYSIS; DIAGNOSIS; 1ST-LINE;
D O I：
10.17221/7140-VETMED
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The aim of this study was to determine the efficacy of a triple anti-Helicobacter therapy using omeprazole, amoxicillin and clarithromycin (OAC) in dogs. A total of 15 healthy adult stray dogs with naturally acquired Helicobacter infection were evaluated using polymerase chain reaction and rapid urease test. Subsequently, they received a 21-day triple regimen. One day after the discontinuation of treatment, a second molecular analysis of gastric biopsies revealed complete eradication of Helicobacter DNA with negative quantitative urease testing in all 15 dogs. Our results confirmed the high prevalence of gastric Helicobacter-like organisms (GHLOs) in the stray dog population of Shiraz, Iran, and the effectiveness of our therapeutic regimen for the complete eradication of these microorganisms in stray dogs. In conclusion, for the complete elimination of non-pylori Helicobacter spp. from the gastric mucosa of dogs, a 21-day three-drug regimen with omeprazole, amoxicillin and clarithromycin is suggested.
引用
收藏
页码：582 / 586
页数：5
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