New Topics in Vasopressin Receptors and Approach to Novel Drugs: Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects

被引：19

作者：

Honda, Kenji ^{[1
]}

Takano, Yukio ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Physiol & Pharmacol, Fukuoka 8140180, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2009年 / 109卷 / 01期

关键词：

arginine vasopressin; V1a receptor; V1b receptor; nociceptive response; morphine-induced response; ANXIETY-RELATED BEHAVIOR; BETA-ENDORPHIN; ARGININE-VASOPRESSIN; SPINAL-CORD; RAT-BRAIN; INTRATHECAL VASOPRESSIN; PARAVENTRICULAR NUCLEUS; INDUCED ANTINOCICEPTION; PERIAQUEDUCTAL GRAY; INDUCED HYPOTHERMIA;

D O I：

10.1254/jphs.08R30FM

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine- induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized the role of V1-receptor subtypes in behavioral responses to noxious stimuli and to morphine. In this review, we focus on studies using mice lacking the Via receptor (V1a(-/-) mice) and the V1b receptor (V1b(-/-) mice).

引用

页码：38 / 43

页数：6

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