The Role of Glycosphingolipids in HIV/AIDS

被引：0
|
作者：
Lingwood, Clifford A. [1 ]
Branch, Donald R. [2 ,3 ]
机构：
[1] Hosp Sick Children, Mol Struct & Funct Program, Toronto, ON M5G 1X8, Canada
[2] Univ Toronto, Dept Med, Toronto, ON M5G 2M1, Canada
[3] Canadian Blood Serv, Toronto, ON M5G 2M1, Canada
来源：
DISCOVERY MEDICINE | 2011年 / 11卷 / 59期
关键词：
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1; INFECTION; GLOBOTRIAOSYL CERAMIDE; ENVELOPE GLYCOPROTEIN; CHEMOKINE RECEPTORS; EPITHELIAL-CELLS; LIPID RAFTS; CONFORMATIONAL-CHANGES; VEROTOXIN BINDING; FUSION COFACTOR;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Much remains unknown about basic aspects of HIV-1 infection and cell susceptibility. Glycosphingolipid (GSL) binding by the HIV-1 adhesin gp120 has long been implicated in the infection of non-lymphoid cells, as well as CD4(+) T cells and monocytes, the primary targets of HIV-1 infection. We have identified the P-k blood group antigen (a GSL) globotriaosylceramide (Gb(3)) as a new resistance effector against HIV-1 infection. Significantly, the alpha-galactosyltransferase (A4GALT, Gb3 synthase) responsible for the synthesis of Gb(3) is included among markers genetically linked to HIV-1 resistance. Other GSLs, including GalCer and GM3, have been implicated as facilitators of HIV infection. This review will address the role of GSLs in HIV/AIDS but focus on the role of Gb(3) as a newly described natural resistance factor for the prevention of HIV infection and examine potential therapies that would utilize soluble analogues of this unique GSL. [Discovery Medicine 11(59):303-313, April 2011]
引用
收藏
页码：303 / 313
页数：11
相关论文
共 50 条
  • [21] The HIV/AIDS pandemic and the evolving role of primary care
    Laurence, J
    AIDS PATIENT CARE AND STDS, 1996, 10 (01) : 2 - 4
  • [22] THE ROLE OF HIV TESTING IN AIDS PREVENTION - KUTCHINSKY,B
    OLSEN, J
    SCANDINAVIAN JOURNAL OF SOCIAL MEDICINE, 1989, 17 (01): : 127 - 127
  • [23] Role of awareness in controlling HIV/AIDS: a mathematical model
    Kaymakamzade B.
    Şanlıdağ T.
    Hınçal E.
    Sayan M.
    Sa’ad F.T.
    Baba I.A.
    Quality & Quantity, 2018, 52 (Suppl 1) : 625 - 637
  • [24] Measurement of the role of families in prevention and adaptation to HIV/AIDS
    Pequegnat W.
    Bauman L.J.
    Bray J.H.
    DiClemente R.
    DiIorio C.
    Hoppe S.K.
    Jemmott L.S.
    Krauss B.
    Miles M.
    Paikoff R.
    Rapkin B.
    Rotheram-Borus M.J.
    Szapocznik J.
    AIDS and Behavior, 2001, 5 (1) : 1 - 19
  • [25] HIV/AIDS in Africa - a role for the mental health practitioner?
    Stein, DJ
    Seedat, S
    Emsley, RA
    Olley, BO
    SAMJ SOUTH AFRICAN MEDICAL JOURNAL, 2005, 95 (03): : 167 - 168
  • [26] Role of IL12 in HIV disease AIDS
    Chougnet, C
    Clerici, M
    Shearer, GM
    RESEARCH IN IMMUNOLOGY, 1995, 146 (7-8): : 615 - 619
  • [27] The Role of Therapeutic Drug Monitoring in Pediatric HIV/AIDS
    Burger, David M.
    THERAPEUTIC DRUG MONITORING, 2010, 32 (03) : 269 - 272
  • [28] The role of HIV in serious diseases other than AIDS
    Phillips, Andrew N.
    Neaton, James
    Lundgren, Jens D.
    AIDS, 2008, 22 (18) : 2409 - 2418
  • [29] A global assessment of the role of law in the HIV/AIDS pandemic
    Gable, L.
    Gostin, L.
    Hodge, J. G., Jr.
    PUBLIC HEALTH, 2009, 123 (03) : 260 - 264
  • [30] Role of abdominal ultrasound in the context of the HIV/AIDS epidemic
    Emby, D. J.
    Igbinedion, B. O-E
    SA JOURNAL OF RADIOLOGY, 2009, 13 (04): : 103 - 104
12345