Synthesis of 1-substituted 5-acetyl (ethoxycarbonyl)-2,3-dihydropyrazolo-[3,4-b]pyridin-3-ones

被引：1
|
作者：
Lebed', P. S. [1 ]
Mozgovaya, N. G. [1 ]
Manoilenko, O. V. [2 ]
Tolmachova, V. S. [3 ]
Vovk, M. V. [1 ]
机构：
[1] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02094 Kiev, Ukraine
[2] Kyiv Taras Shevchenko Natl Univ, UA-01033 Kiev, Ukraine
[3] M Dragomanov Natl Pedag Univ, UA-01601 Kiev, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 48卷 / 07期
关键词：
5-acetyl-4-methyl-1,2-dihydropyrazolo[3,4-b]pyridin-3-ones; 1-substituted; 5-aminopyrazol-3-ones; ethyl 4-hydroxy-3-oxo-2,3-dihydropyrazolo[3,4-b]pyridine-5-carboxylate; ethoxymethylidene-beta-dicarbonyl compounds; PDE4; INHIBITORS; DERIVATIVES;
D O I：
10.1007/s10593-012-1099-7
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1-Substituted 5-aminopyrazol-3-ones react selectively with ethoxymethylidene beta-dicarbonyl compounds (3-ethoxymethylidene-2,4-pentanedione, diethyl 2-ethoxymethylidenemalonate, and ethyl 2-ethoxy-methylideneacetoacetate) with the formation of dihydropyrazolylaminomethylidene beta-dicarbonyl derivatives, which undergo thermal intramolecular cyclization to 5-functionalized dihydro-pyrazolo[3,4-b]pyridin-3-ones.
引用
收藏
页码：1058 / 1063
页数：6
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